01 January 1999
Serum cytokines concentrations in patients with infective endocarditis. A possible role in diagnosis and monitoring
Irena Rawczyńska-Englert, Tomasz Hryniewiecki, Danuta DzierżanowskaMed Sci Monit 1999; 5(1): CR89-92 :: ID: 505260
Abstract
Introduction: Early diagnosis of infective endocarditis is important for the clinical outcome since mortality increases with a longer diagnostic delay. The diagnosis of infective endocarditis is mainly based on clinical features, echocardiography and blood culture findings. Unfortunately negative blood cultures have been reported in up to 30% of proved cases. The aim of the study was to investigate usefulness of serum cytokines concentrations in diagnosis and monitoring of infective endocarditis.
Material and Method: The study group consisted of 30 patients with acquired rheumatic valvular heart diseases and ongoing infective endocarditis. The diagnosis of infective endocarditis was established on clinical examination, echocardiography, laboratory investigations (inflammatory parameters) and positive blood cultures (in 26 patients). Control group consisted of 10 patients with acquired rheumatic valvular heart diseases without infective endocarditis. Serum interleukin-1a (IL-1a), interleukin-6 (IL-6) and a tumor necrosis factor-a (TNF-a) concentrations were measured three times during antimicrobial treatment (mean interval 16±8 days).
Results: Serum IL-1a and TNF-a concentrations were not elevated in any patient or control (IL-1a<3.9 pg/ml, TNF-a<10 pg/ml - below calibration range). Serum IL-6 concentrations were elevated in all measuring points in patients with infective endocarditis (first: 36.7±48.1, second: 19.2±17.5 third: 8.7±5.7 pg/ml) with a significant tendency to decrease during treatment (ANOVA, p<0.01). In all controls serum IL-6 concentrations were below calibration range (<3.2 pg/ml).
Conclusions: 1. Elevated serum IL-6 concentrations may suggest ongoing infective endocarditis and could be an additional parameter in diagnosis and monitoring treatment of the disease. 2. Serum IL-1a and TNF-a concentrations were not affected. Further understanding the role of serum cytokines concentrations in diagnosing, prognosis and monitoring of infective endocarditis could be useful in clinically uncertain diagnosis especially while blood cultures are negative.
Keywords: Cytokines, infective endocarditis, Diagnosis
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952