01 January 1999
Blood fructosamine levels in patients with primary and metastatic brain tumors
Barbara Chmielewska, Ewa Belniak-Legieć, Zbigniew StelmasiakMed Sci Monit 1999; 5(1): CR58-61 :: ID: 505219
Abstract
Hyperglikemia increases the blood protein glycosylated reaction. Central nervous system (CNS) organic diseases may change the systemic metabolism. The aim of this study was to evaluate blood glycosylated protein levels (fructosamine - FA) in patients with CNS tumors. Patients were divided into two groups: those with a primary brain tumor (n=12, mean age - 58 years) and those with a metastatic brain tumor (n=12, mean age - 57.9), without diabetes or cachexy. Their protein, albumin and glucose levels were within normal values. We determined FA levels by means of the frustosamine reductive method in relation to nitrotetrazoline blue, using the Boehringer Mannheim GmbH Diagnostica set. p < 0.02 was considered as statistically significant, evaluated by means of the Mann-Whitney U test. The control group comprised 11 patients (mean age - 63.7 years). We noted an increase in fructosamine levels in patients with CNS tumors. A statistically significant difference was observed in patients with metastatic tumors, in comparison with controls (287.8 µmol/l vs. 214.9 µmol/l). An elevation in FA levels was evidence of increased glycosylation, in CNS tumor patients, due to an increase of mean glucose values in the past 2-4 weeks.
Keywords: primary brain tumors, serum fructosamine level, adults
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952