01 March 1999
Osteocalcin, estradiol and prolactin concentrations in women receiving long-term estradiol replacement therapy
Aleksandra Kochańska-Dziurowicz, Władysław Gaweł, Ewa WidalaMed Sci Monit 1999; 5(2): CR258-261 :: ID: 505112
Abstract
The aim of this study was to assess the effects of long-term hormonal replacement therapy (HRT) on estradiol, prolactin and osteocalcin levels depending on the route of drug administration. The study group comprised 45 perimenopausal women receiving estradiol either orally or transdermally. 31 untreated women served as the control group. All women had undergone gynecological and general examinations as well as examinations of bone density. All patients included into the survey presented no signs of bone loss and had no history of known osteoporosis risk factors. Osteocalcin, estradiol and prolactin concentrations were measured by means of radioimmunoassays. We demonstrated that the transdermal route of estrogen administration provides better control of estradiol levels and bone remodelling, expressed by a more stable distribution of the measured parameters, when compared with the group receiving oral preparations. We also noted that long-term hormonal replacement therapy does not significantly change prolactin secretion.
Keywords: Menopause, osteocalcin, prolactin, estradiol replacement therapy
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952