30 April 1999
Side effects of alpha interferon (INF) therapy with special reference to autoaggression processes in children with chronic hepatitis B
Dariusz Marek Lebensztejn, Maciej KaczmarskiMed Sci Monit 1999; 5(3): CR510-513 :: ID: 504908
Abstract
The aim of the study was to evaluate the frequency of side effects in children with chronic hepatitis (ch) B treated with IFN alpha. 69 children with clinical and histopathological diagnosis of ch were included in the study. IFN was used in the dose of 3 million IU 3 times a week for 20 weeks, monitoring adverse events associated with the administration of the drug. Autoimmune reactions were evaluated in 39 children on the basis of ANA presence in blood serum. The following were observed during interferon-therapy: fever - 100% children, lack of appetite - 45%, irritability - 30%, articular-muscular pain - 22%, dyspeptic symptoms - 20%, hair loss - 12%, dermal lesions - 7%, convulsions, leukopenia, thrombocytopenia or excessive appetite - 3%, polyuria - 1.5%. These symptoms withdrew during or after therapy with IFN. The presence of ANA in blood serum of 39 analysed patients was detected in 18% before the beginning of treatment and in 21% children after therapy completion. Conclusion: Side effects occurring in children with ch B during treatment course with IFN alpha are transient and do not affect drug safety.
key words: chronic hepatitis, HBV, interferon alpha, side effects, children
Keywords: chronic hepatitis, interferon alpha, side effects, children, HBV
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952