30 April 1999
Diagnostic value of 15-3 antigen (CA 15-3) in serum of women with breast cancer - comparison to mucin-like associated antigen (MCA)Zygmunt Kopczyński, Anna Thielemann, Izabella Konik, Izabela Szczypińska
Med Sci Monit 1999; 5(3): BR415-420 :: ID: 504742
The aim of this study was evaluation of the independence occurence of CA 15-3 and MCA in serum of women with breast cancer. Relationship between the concentration of these antigens and patient age, stage of the clinical progression, histopathological grade, presence of metastases to the axillary lymph nodes and histological type of neoplasm was evaluated. The studies were carried out on the serum of 131 women aged 25-81 years (age average 53 years), treated in the Surgial Department in the Chair of Oncology at Karol Marcinkowski Medical University. The MCA concentration was determined by means of the immunoenzymatic assay by Roche (Austria) and the contents of CA 15-3 was obtained due to the Abbott immunofluorescent method (U.S.A.). The study showed that CA 15-3 and MCA serum concentrations in healthy women remained within acceptable values. A slight percentage of the increased antigen concentrations was revealed in the serum of women with a benign breast neoplasm. However, in women with breast cancer there was the most significant level of CA 15-3 (40%) and of MCA (31.4%). The higher clinical stage the higher median of CA 15-3 concentration was noted. There is no such a correlation as far as MCA is concerned. The higher the histological grade the lower the value of CA 15-3. The data analyses indicated that the biggest percentage of elevated results was MCA and CA 15-3 in the serum of women with lobular cancer. The study suggests some valuable hints how to determine antigens in the serum. Especially CA 15-3 can put forward information helpful to establish a diagnosis. It may also be needed as far as the assessment of the clinical stage of the disease is concerned. It also has prognostic value.
Keywords: mucin-like associated antigen, antigen CA 15-3, breast cancer
01 December 2021 : EditorialEditorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19
Med Sci Monit 2021; 27:e935624
03 December 2021 : Laboratory ResearchInfluenza and Influenza-Like Respiratory Virus Infections in Children During the 2019/20 Influenza Season a...
Med Sci Monit In Press; DOI: 10.12659/MSM.934862
08 November 2021 : Database AnalysisVirtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Cor...
Med Sci Monit In Press; DOI: 10.12659/MSM.934102
01 November 2021 : EditorialEditorial: What Can be Learned from National and International Vaccine Adverse Event Reporting Systems Duri...
Med Sci Monit 2022; 28:e935299
06 Dec 2021 : Animal ResearchAstragalus Flavone Induces Proliferation and Differentiation of Neural Stem Cells in a Cerebral Infarction ...
Med Sci Monit In Press; DOI: 10.12659/MSM.933830
06 Dec 2021 : Clinical ResearchAlteration of Serum Metabolites in Women of Reproductive Age with Chronic Constipation
Med Sci Monit In Press; DOI: 10.12659/MSM.934117
06 Dec 2021 : Clinical ResearchBody Composition Changes and Related Factors in Patients with Ulcerative Colitis: A Retrospective Single-Ce...
Med Sci Monit In Press; DOI: 10.12659/MSM.933942
Most Viewed Current Articles
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700