Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

01 July 1999

Immunogenetic aspects of coeliac disease in children

Anna Kędzierska

Med Sci Monit 1999; 5(4): CR732-740 :: ID: 504537


The role of genetic factors predisposing to the occurrence of coeliac disease was supported by the demonstration of differences in the distribution of many genetic markers Ñ HLA system. The aim of the study was an attempt of genetic analysis of the existence of specific familial and allelic interrelationship in the secretion of certain class I HLA antigens (sHLA-I) in coeliac disease. The analysis included sHLA-I concentrations with reference to the associations between phenotype expression of certain HLA-I antigens (A1, B8) and disease manifestation. The study included: 425 serum samples obtained from children with coeliac disease (n=69), 319 serum samples obtained from their healthy siblings (n=49), 549 serum samples from probands' parents (n=91). Antigens HLA loci ABC were typed in a two-gradual microcytotoxic test according to NIH. Immunogenetic comparative analysis was related to the frequency of phenotypes and haplotypes in 1152 and 616 unrelated healthy persons, respectively. The following indices were determined: relative risk (RR) according to Svejgaard et al, etiologic fraction (EF, EFe) and preventive fraction (PF, PFE) according to Green. The level of sHLA-I determined in a semi-quantitative microabsorption test according to McLean et al. was compared with that obtained in 1515 sera of 248 persons forming control population. sHLA level for 13 antigens from locus A, 19 from locus B, 7 from locus C and markers of biallelic Bw4/Bw6 system was given as a sum of points of the inhibition of cytotoxic reaction. Positive associations  (p<0.0000...1) were observed for the following: HLA-A1, -B8,-Cw7, while negative associations were observed for HLA-A2. Haplotype HLA-A1-B8-Cw7 occurred significantly more frequently than in control group (p<0.000013Ð0.0000...1). There was a highly significantly lower
level of sHLA-ABC (p<0.0000...1) in sera of children with coeliac disease for: HLA-A1, A11, A32, B13, B27, B44, B51, Bw6, Cw1 and Cw3, while there was a significantly lower level of sHLA for sHLA-B38 (p<0.0052), B55 (p<0.0312) and Cw6 (p<0.0442). Significantly higher secretion was proved for sHLA-A23, Bw4 and Cw2. In the sera of siblings and parents, significantly lower differences of sHLA-I concentrations were observed in both cases for 3 antigens HLA-A (A11, A24, A32), 7 HLA-B (B13, B38, B39, B44, B51, B57, Bw6) and 3 HLA-C (Cw1, Cw3, Cw6). The detection of the presence of antigens HLA-A1, -B8 is a predisposing factor to the occurrence of hypersensitivity to gluten. Familial occurrence of decreased secretion of the same antigens may indicate the existence of common immunogenetic background for coeliac disease in this respect.

Keywords: soluble form of class I HLA antigens (sHLA-I), coeliac disease, HLA system, MHC


This Week Editorial

20 September 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934766

Med Sci Monit 2021; 27:e934766

Coronavirus/Covid 19

22 September 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

23 Sep 2021 : Animal Research

Forkhead Box Protein M1 Promotes Nasopharyngeal Carcinoma Cell Tumorigenesis Possibly via the Wnt/β-Catenin...

Med Sci Monit In Press; DOI: 10.12659/MSM.931970  

22 Sep 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

22 Sep 2021 : Clinical Research

A Comparative Study of the Clinical Efficacy and Safety of Pneumatic Trabeculoplasty and Selective Laser Tr...

Med Sci Monit In Press; DOI: 10.12659/MSM.933454  

20 Sep 2021 : Clinical Research

Comparison of the Use of Magnetic Resonance Imaging of Partial Anterior Cruciate Ligament Tears Using Maxim...

Med Sci Monit In Press; DOI: 10.12659/MSM.932228  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750