Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

01 July 1999

Significance of densitometry and biochemical tests in diagnosis of osteoporosis in children suffering from juvenile rheumatoid arthritis

Danuta Chlebna-Sok—ół, Henryka Bró—zik, Tadeusz Bujnowski, Małgorzata Biernacka, Elżbieta Loba-Jakubowska, Anna Sikora, Elżbieta Smolewska

Med Sci Monit 1999; 5(4): CR720-725 :: ID: 504497

Abstract

Background:The aim of this study was to evaluate the role of different tests in the diagnosis of osteoporosis, in children suffering from juvenile rheumatoid arthritis (JRA), as well as to assess the correlation between test results and clinical disease symptoms.
Material/Methods:Tests were performed in 30 children aged between 5-18 years (24 girls, 6 boys), suffering from juvenile rheumatoid arthritis. We evaluated the bone mineral density (BMD - g/cm2, Z-score) by means of dual energy X-ray absorptiometry (DEXA method) using the 'total body' program in all children and in some by means of the lumbar vertebral column using the 'spine' program. Moreover, we also determined the serum calcium, phosphorus and magnesium levels, as well as the urine excretion of these ions and that of total hydroxyproline. We measured the activity of alkaline phosphatase and its bone isoenzyme, as well as 25-hydroxyvitamin D and parathyroid hormone levels.
Results:Based on bone densitometry results osteoporosis was diagnosed in 12 of the patients with JRA (40%). These children demonstrated clinical and radiological manifestations of osteoporosis. Distinct biochemical test abnormalities included decreased parathyroid hormone, 25-hydroxycholecalciferol vitamin D and magnesium blood concentrations and increased hydroxyproline excretion with urine. Such abnormalities also appeared in children with JRA but without osteoporosis, although less frequently. The longer the disease had lasted the lower the bone mineral density.
Conclusions:Densitometry should be considered as the most important and objective method of diagnosing osteoporosis in children with JRA. Urine hydroxyproline excretion seems to be of great practical significance amongst biochemical indices.

Keywords: densitomery, Diagnosis, Osteoporosis

0 Comments

This Week Editorial

27 September 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic Monoclonal Antibody for Advanced Non-Small Cell Lung Cancer (NSCLC)

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934854

Med Sci Monit 2021; 27:e934854

Coronavirus/Covid 19

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

24 Sep 2021 : Clinical Research

A Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...

Med Sci Monit In Press; DOI: 10.12659/MSM.933809  

24 Sep 2021 : Database Analysis

Relationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)

Med Sci Monit In Press; DOI: 10.12659/MSM.933448  

24 Sep 2021 : Database Analysis

A Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors

Med Sci Monit In Press; DOI: 10.12659/MSM.933559  

24 Sep 2021 : Clinical Research

Value of Ocular Endoscopy in Extraction of Intraocular Foreign Bodies of Cilia in Patients with Open Ocular...

Med Sci Monit In Press; DOI: 10.12659/MSM.932970  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750