01 July 1999
Significance of densitometry and biochemical tests in diagnosis of osteoporosis in children suffering from juvenile rheumatoid arthritisDanuta Chlebna-Sokół, Henryka Brózik, Tadeusz Bujnowski, Małgorzata Biernacka, Elżbieta Loba-Jakubowska, Anna Sikora, Elżbieta Smolewska
Med Sci Monit 1999; 5(4): CR720-725 :: ID: 504497
Background:The aim of this study was to evaluate the role of different tests in the diagnosis of osteoporosis, in children suffering from juvenile rheumatoid arthritis (JRA), as well as to assess the correlation between test results and clinical disease symptoms.
Material/Methods:Tests were performed in 30 children aged between 5-18 years (24 girls, 6 boys), suffering from juvenile rheumatoid arthritis. We evaluated the bone mineral density (BMD - g/cm2, Z-score) by means of dual energy X-ray absorptiometry (DEXA method) using the 'total body' program in all children and in some by means of the lumbar vertebral column using the 'spine' program. Moreover, we also determined the serum calcium, phosphorus and magnesium levels, as well as the urine excretion of these ions and that of total hydroxyproline. We measured the activity of alkaline phosphatase and its bone isoenzyme, as well as 25-hydroxyvitamin D and parathyroid hormone levels.
Results:Based on bone densitometry results osteoporosis was diagnosed in 12 of the patients with JRA (40%). These children demonstrated clinical and radiological manifestations of osteoporosis. Distinct biochemical test abnormalities included decreased parathyroid hormone, 25-hydroxycholecalciferol vitamin D and magnesium blood concentrations and increased hydroxyproline excretion with urine. Such abnormalities also appeared in children with JRA but without osteoporosis, although less frequently. The longer the disease had lasted the lower the bone mineral density.
Conclusions:Densitometry should be considered as the most important and objective method of diagnosing osteoporosis in children with JRA. Urine hydroxyproline excretion seems to be of great practical significance amongst biochemical indices.
Keywords: densitomery, Diagnosis, Osteoporosis
This Week Editorial
27 September 2021 : EditorialEditorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic Monoclonal Antibody for Advanced Non-Small Cell Lung Cancer (NSCLC)
Med Sci Monit 2021; 27:e934854
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
09 July 2021 : Database AnalysisA Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...
Med Sci Monit In Press; DOI: 10.12659/MSM.931467
24 Sep 2021 : Clinical ResearchA Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...
Med Sci Monit In Press; DOI: 10.12659/MSM.933809
24 Sep 2021 : Database AnalysisRelationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)
Med Sci Monit In Press; DOI: 10.12659/MSM.933448
24 Sep 2021 : Database AnalysisA Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors
Med Sci Monit In Press; DOI: 10.12659/MSM.933559
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700