Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

01 July 1999

Low urinary kallikrein excretion in normotensive offsprings of hypertensive parents

Andrzej Ciechanowicz, Justyna Marzęcka, Teresa Wesołowska, Mariusz Kaczmarczyk, Krzysztof Klimek, Eugeniusz Szmatłoch

Med Sci Monit 1999; 5(4): CR687-691 :: ID: 503490


The kallikrein-kinin system is involved in the regulation of blood pressure. The previous studies have shown a correlation between the family history of hypertension and decreased urinary kallikrein excretion (UKE). In order to analyse this issue further, we evaluated UKE, blood pressure, plasma renin activity (PRA) and plasma aldosterone concentration (PAC) as well as urinary excretion of sodium and potassium (uNa+ and uK+, respectively) in 85 normotensive young lean adults classified according to the prevalence of essential hypertension in parents. Mean arterial pressure (MAP) in offsprings of both hypertensive parents (FH/P group) was significantly higher but in normal range when compared with offsprings of both normotensive parents (NFH group). The UKE in offsprings of either hypertensive mother or hypertensive father (FH/M or FH/F group, respectively) was only slightly lower when compared with values in NFH group. In contrast, the UKE in offsprings of both hypertensive parents was significantly lower when compared with NFH subjects. According to phenotype of kallikrein excretion, the participants were classified as Low Kallikrein (LK, UKE at and below 3.8 nkat/24h, n=27), Intermediate Kallikrein (IK, UKE 4.3Ð10.5 nkat/24h, n=49) and High Kallikrein (HK, UKE at and above 14.4 nkat/24h, n=9). There were no significant differences in frequency of particular phenotype among NFH, FH/M, FH/F and FH/P groups. The only PRA was significantly lower in LK group as compared with non-LK group. The weak but significant correlation between UKE and PRA as well as between UKE and uK+ has been found in the whole studied group. Our results confirm the interrelationship between low UKE and family history of hypertension.
key words: urinary kallikrein excretion, family history of hypertension

Keywords: family history of hypertension, urinary kallikrein excretion


This Week Editorial

20 September 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934766

Med Sci Monit 2021; 27:e934766

Coronavirus/Covid 19

22 September 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

23 Sep 2021 : Animal Research

Forkhead Box Protein M1 Promotes Nasopharyngeal Carcinoma Cell Tumorigenesis Possibly via the Wnt/β-Catenin...

Med Sci Monit In Press; DOI: 10.12659/MSM.931970  

22 Sep 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

22 Sep 2021 : Clinical Research

A Comparative Study of the Clinical Efficacy and Safety of Pneumatic Trabeculoplasty and Selective Laser Tr...

Med Sci Monit In Press; DOI: 10.12659/MSM.933454  

20 Sep 2021 : Clinical Research

Comparison of the Use of Magnetic Resonance Imaging of Partial Anterior Cruciate Ligament Tears Using Maxim...

Med Sci Monit In Press; DOI: 10.12659/MSM.932228  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750