01 July 1999
Effect of application of n-3 polyunsaturated fatty acids on blood serum concentration of von Willebrand factor in type II diabetes mellitusPeter Haban, Robert Simoncic, Jana Klvanova, Eva Zidekova
Med Sci Monit 1999; 5(4): CR661-665 :: ID: 503471
Increased concentration of von Willebrand factor (vWF) is generally accepted as independent risk factor for cardiovascular complications in type 2 diabetes. In attempt to decrease its blood serum concentration, 34 patients with type 2 diabetes mellitus were supplemented for 28 days with 1.7 g of eicosapentaenoic acid (EPA) plus 1.15 g docosahexaenoic acid (DHA)per each day, followed by a 3 months' wash-out control period with20 patients. After the period of supplementation with EPA and DHA, there was a significant decline in vWF by 15.66 % of ref. plasma (95% CI 6.13, 25.19) followed by its significant increase during the wash-out (on average by 19.15 %; 95% CI 1.24, 37.06). Changes in vWF (DvWF) after intervention correlated with vWF baseline values (r=Ð0.415; p=0.015) and during the entire follow-up (intervention + wash-out) also inversely with changes in EPA, DHA and 22: 5n3 (docosapentaenoic acid) in serum phospholipids (r=Ð0.409, r=-0.454, r=-0.418; p=0.002, p=0.0006, p=0.002, respectively). Supplementation with long-chain n-3 PUFAs (incl. EPA and DHA) in this indication seems to be beneficial also because of its other effects, e. g. on lipoprotein and eicosanoid spectrum, blood rheology etc.
Keywords: n-3 fatty acids, von Willebrand Factor, type 2 diabetes
This Week Editorial
20 September 2021 : EditorialEditorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19
Med Sci Monit 2021; 27:e934766
22 September 2021 : EditorialEditorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...
Med Sci Monit In Press; DOI: 10.12659/MSM.934854
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
24 Sep 2021 : Clinical ResearchA Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...
Med Sci Monit In Press; DOI: 10.12659/MSM.933809
24 Sep 2021 : Database AnalysisRelationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)
Med Sci Monit In Press; DOI: 10.12659/MSM.933448
24 Sep 2021 : Database AnalysisA Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors
Med Sci Monit In Press; DOI: 10.12659/MSM.933559
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700