01 July 1999
Activity of acid phosphatase, arylsulphatase and cathepsin D in blood serum of patients with psoriasis before and after therapy - a preliminary studyGerard Drewa, Zenon Gwiezdziński, Ewa Krzyżyńska-Malinowska, Radosław Maciak, Małgorzata Rozwodowska, Alina Wozniak, Bartosz Wozniak, Katarzyna Kowalke
Med Sci Monit 1999; 5(4): CR656-660 :: ID: 503469
The activity of three lysosomal enzymes - acid phosphatase, arylsulphatase and cathepsin D was determined in blood serum of 22 patients with psoriasis and in 22 healthy subjects. Patients' age ranged between 15 and 61 years. Patients received treatment according to conventional methods. The activity of acid phosphatase in blood serum of patients with psoriasis did not differ from that observed in control group, and it was 7.6×10-3 nM, while the activity of cathepsin D was 18% higher in relation to control group and it was 80 × 10-3 nM. Differences in the activity of arylsulphatase and cathepsin D were statistically significant. The treatment applied resulted in the return of enzyme activity to the values observed in healthy people. It is presumed that lysosomal hydrolases may play some role in the pathogenesis of psoriasis.
Keywords: Psoriasis, Cathepsin D, arylsulphatase, Acid Phosphatase, Lysosomal enzymes
This Week Editorial
20 September 2021 : EditorialEditorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19
Med Sci Monit 2021; 27:e934766
22 September 2021 : EditorialEditorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...
Med Sci Monit In Press; DOI: 10.12659/MSM.934854
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
24 Sep 2021 : Clinical ResearchA Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...
Med Sci Monit In Press; DOI: 10.12659/MSM.933809
24 Sep 2021 : Database AnalysisRelationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)
Med Sci Monit In Press; DOI: 10.12659/MSM.933448
24 Sep 2021 : Database AnalysisA Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors
Med Sci Monit In Press; DOI: 10.12659/MSM.933559
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700