Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

4G/5G polymorphism in the promoter of plasminogen activator inhibitor-1 (PAI-1) gene in subjects with node-negative and node-positive breast cancer

Beata Smolarz, Janusz Błasiak, Jacek Pytel, Hanna Romanowicz-Makowska, Marek Zadrożny

Med Sci Monit 1999; 5(5): BR833-837 :: ID: 503262

Abstract

PAI-1 is a serine protease inhibitor involved in the degradation of the extracellular matrix during malignant tumor invasion and its high level in breast cancer is associated with a poor prognosis for patients. It is supposed that 4G/5G insertion/deletion polymorphism, with a sequence of either four guanosines or five guanosines, in the promoter of the PAI-1 gene may play a functional role in PAI-1 synthesis, affecting the level of circulating PAI-1. To investigate whether the progression of breast cancer may be related to a particular genotype, 4G/5G polymorphism in patients with node-negative (n=17) and node-positive (n=20) breast cancer was studied. The subjects were 44 to 82 years old, with a median age of 59 years. Formalin-fixed, paraffin-embedded material from ductal breast carcinoma was used. The tumors' diameter was about 20 mm and they were classified of II, II°, III or III°grade. The 4G/5G polymorphism of PAI-1 gene was determined by the allele specific polymerase chain reaction (ASO-PCR). The genotype distribution differed significantly between node-negative and node-positive groups. The 4G allele was observed more frequently in node-negative patients (0.74) compared with 5G allele (0.26), whereas in subjects with node-positive the frequency 4G and 5G allele were 0.48 and 0.52, respectively. Different distribution of the 4G/5G genotypes in patients indicate that this genetic variation itself may be a risk factor for breast cancer invasive phenotype, so the association of the 4G/5G polymorphism with breast cancer progression is worth further studying.

Keywords: PAI-1 - plasminogen activator inhibitor-1, 4G/5G polymorphism, prognostic factor, node-negative and node-positive breast cancer, allele specific polymerase chain reaction (ASO-PCR)

Comments

Editorial

01 May 2022 : Editorial  

Editorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937048

Med Sci Monit 2022; 28:e937048

SARS-CoV-2/COVID-19

24 May 2022 : Clinical Research  

Screening for SARS-CoV-2 Infection in Students at the Medical University of Warsaw, Poland Between November...

Med Sci Monit In Press; DOI: 10.12659/MSM.936962  

04 May 2022 : Clinical Research  

Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936069  

22 April 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit In Press; DOI: 10.12659/MSM.936547  

In Press

25 May 2022 : Review article  

Narrative Review of the Mechanism of Hip Prosthesis Dislocation and Methods to Reduce the Risk of Dislocation

Med Sci Monit In Press; DOI: 10.12659/MSM.935665  

24 May 2022 : Clinical Research  

Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936580  

24 May 2022 : Clinical Research  

Screening for SARS-CoV-2 Infection in Students at the Medical University of Warsaw, Poland Between November...

Med Sci Monit In Press; DOI: 10.12659/MSM.936962  

23 May 2022 : Clinical Research  

Fully Automatic Knee Joint Segmentation and Quantitative Analysis for Osteoarthritis from Magnetic Resonanc...

Med Sci Monit In Press; DOI: 10.12659/MSM.936733  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750