01 November 1999
Activity of prekallikrein and C1 inhibitor in patients with bronchial asthma
Ewa Banach-Wawrzeńczyk, Andrzej Dziedziczko, Danuta RośćMed Sci Monit 1999; 5(6): CR1118-1122 :: ID: 503149
Abstract
Bronchmial asthma is cinsidered an inflammatory disease. The mediators participating in the inflammatory process include kinins. The aim of the present study was to evaluate kinin system in patients with bronchial asthma directly after the establishment of the diagnosis. The investigations were performed in 21 patients with bronchial asthma as well as in 22 healthy volunteers. The plasma obtained from study subjects was used to determine the activity of prekallikrein (with photometry, test C manufactured by Chromogenix) and the activity of C1 inhibitor (following the method designed by Behring company) with the use of chromogenic substrates. When compared with healthy subjects, the patients with bronchial asthma displayed statistically significantly lower activity of prekallikrein (p < 0.01) and C1 inhibitor (p < 0.001). Study results indicate that reduced activity of prekallikrein and C1 inhibitor in patients with bronchial asthma is the consequence of their consumption in the process of kinin activation in the course of inflammation.
key words: prekallikrein • C1 inhibitor • bronchial asthma
Keywords: bronchial asthma, C1 inhibitor, Prekallikrein
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952