Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

01 November 1999

Plasma nitrate/nitrite levels in patients with colorectal carcinoma

Erika Szaleczky, Andra‡s Rosta, Hiroe Nakazawa, J‡anos FehŽer, Zsolt Tulassay, L‡aszlo Pro—nai

Med Sci Monit 1999; 5(6): CR1098-1100 :: ID: 503105


Endogenously formed nitroso-compounds and nitrite-derived mutagens are believed to be involved in human cancer etiology. These nitroso-compounds can be formed from nitric oxide by macrophages and neutrophils by means of the inducible nitric oxide synthase. Increased nitric oxide synthase expression has been reported in patients with colon carcinoma. Since endogenous nitric oxide synthesis is responsible for the majority of plasma nitrate/nitrite levels, we investigated plasma nitrate/nitrite levels in colorectal carcinoma patients (mean age 66±2.2 y.). Thirteen healthy volunteers comprised the control group (mean age 28±1.9 y.). All patients had been diagnosed with adenocarcinoma (11 rectum, 12 colon, 2 both the rectum and colon), mostly within one year of the study and 50% of patients underwent surgery and/or chemotherapy within one month of the study.Thirteen patients were classified as stage B or C and 15 patients had stage D, according to the Dukes classification modified by Astler-Coller and Turnbull. Since cardiac failure and nitric oxide releasing drugs (such as nitroglycerine) may increase plasma nitrate/nitrite levels, patients had also been divided according to their medication and cardiac condition. Considering the total number of patients, cancer patients demonstrated no statistically different plasma nitrate/nitrite levels, in comparison with healthy controls. However, patients with a tumor diagnosed more than a half year prior to the study, had significantly higher nitrate/nitrite levels compared to the group of patients diagnosed within six months of the study (p=0.03). Patients who underwent chemotherapy within one month of the study, also demonstrated significantly higher nitrate/nitrite levels compared to the group of patients who had no chemotherapy during the past four weeks (p=0.04). Plasma nitrate/nitrite levels were higher in patients with no prior surgery. There was no statistically significant difference in patients when assessing the location of the tumor, presence or absence of distal metastasis, medication used or cardiac condition.Actual plasma nitrate/nitrite levels are indirect measures of malignant diseases. They do not reflect earlier staging, location or severity of the colorectal carcinoma but seem to positively correlate with the duration of the disease. Chemotherapy increases plasma nitrate/nitrite levels by enhancing cell degradation.

Keywords: peroxynitrite, Nitric Oxide, colorectal cancer


This Week Editorial

20 September 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934766

Med Sci Monit 2021; 27:e934766

Coronavirus/Covid 19

22 September 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

24 Sep 2021 : Clinical Research

A Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...

Med Sci Monit In Press; DOI: 10.12659/MSM.933809  

24 Sep 2021 : Database Analysis

Relationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)

Med Sci Monit In Press; DOI: 10.12659/MSM.933448  

24 Sep 2021 : Database Analysis

A Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors

Med Sci Monit In Press; DOI: 10.12659/MSM.933559  

24 Sep 2021 : Clinical Research

Value of Ocular Endoscopy in Extraction of Intraocular Foreign Bodies of Cilia in Patients with Open Ocular...

Med Sci Monit In Press; DOI: 10.12659/MSM.932970  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750