Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 1999

Influences of dilute acetic acid on rat stomachs following acute and chronic exposure-induction of adaptive gastric cytoprotection

Shinichi Sugamoto, Shoji Kawauchi, Osamu Furukawa, Koji Takeuchi

Med Sci Monit 1999; 5(6): BR1031-1038 :: ID: 502877

Abstract

Aim: Influence of acute or chronic exposure of the stomach to dilute acetic acid was examined in rats.Methods: Rats were given acetic acid (0.1-1.0%) p.o. acutely or twice daily for 4 weeks, and subsequently the gastric potential difference (PD), mucosal blood flow (GMBF) or ulcerogenic response to HCl/etahnol were examined.
Results: Acute exposure of the rat stomach to dilute acetic acid for 10 min caused a concentrationdependent reduction of PD and increase of GMBF. The acetic acid given acutely also reduced the severity of HCl/ethanol-induced gastric lesions in a concentration-dependent manner. The protective effect of acetic acid was significantly attenuated by prior administration of indomethacin (5 mg/kg) but not by NG-nitro-L-arginine methyl ester (L-NAME) or sensory deafferentation, although the increased GMBF response was partially mitigated by either indomethacin, L-NAME or sensory deafferentation. The mucosal exposure to 1% acetic acid for 10 min significantly increased the luminal release of PGE2, and this response was completely inhibited by indomethacin but not by L-NAME. Likewise, a similar gastroprotection was observed when acetic acid was given repeatedly for 4 weeks before challenge with HCl/ethanol, the effect being also reversed in the presence of indomethacin. Citric acid even at 1% had no effect on both gastric PD, GMBF and HCl/ethanol-induced gastric damage, by either acute or chronic treatment.
Conclusion: These results suggest that dilute acetic acid such as vinegar acts as a mild irritant to the stomach, resulting in adaptive cytoprotection with an increase of GMBF, and the protective action is mainly brought about by endogenous prostaglandins while the latter is mediated, at least partly, by nitric oxide and sensory neurons, in addition to prostaglandins.

Keywords: Acetic Acid, Gastric Mucosa, adaptive cytoprotection ethanol damage, endogenous prostaglandins

0 Comments

Editorial

01 May 2022 : Editorial  

Editorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937048

Med Sci Monit 2022; 28:e937048

SARS-CoV-2/COVID-19

16 May 2022 : Clinical Research  

Importance of Influenza Anti-Hemagglutinin Antibodies During the SARS-CoV-2 Pandemic in the 2019/2020 Epide...

Med Sci Monit In Press; DOI: 10.12659/MSM.936495  

04 May 2022 : Clinical Research  

Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936069  

22 April 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit In Press; DOI: 10.12659/MSM.936547  

27 April 2022 : Meta-Analysis  

Effect of the COVID-19 Pandemic on Serum Vitamin D Levels in People Under Age 18 Years: A Systematic Review...

Med Sci Monit In Press; DOI: 10.12659/MSM.935823  

In Press

18 May 2022 : Clinical Research  

Physical and Psychosocial Concept Domains Related to Health-Related Quality of Life (HRQL) in 50 Girls and ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936801  

18 May 2022 : Clinical Research  

Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Haina...

Med Sci Monit In Press; DOI: 10.12659/MSM.936134  

17 May 2022 : Clinical Research  

Clinical Application of C-TIRADS Category and Contrast-Enhanced Ultrasound in Differential Diagnosis of Sol...

Med Sci Monit In Press; DOI: 10.12659/MSM.936368  

17 May 2022 : Laboratory Research  

Artificial Dermal Scaffold Loaded with Platelet-Rich Plasma Promotes Wound Healing in Pigs by Favoring Angi...

Med Sci Monit In Press; DOI: 10.12659/MSM.936186  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750