H-Index
79
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
15%
Acceptance
Rate
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Logo



eISSN: 1643-3750

Influence of cholesterol liposome immunisation and immunostimulation on rabbits atherosclerosis induced by a high cholesterol diet

Istvan Horva‡th, Bela Szende, Anna Horva‡th, Kocsis Ibolya, Attila Horva‡th

Med Sci Monit 1998; 4(3): BR403-407

ID: 502387

Available online: 1998-05-01

Published: 1998-05-01


We studied the development of atherosclerosis in rabbits immunized with cholesterol liposomes and fed with cholesterol. Immunization was combined with immunostimulation (CDM, a Gram negative bacterial product). Cholesterol liposome immunization prevented the development of aortic atherosclerosis and significantly decreased the serum cholesterol level in comparison with the control group. These effects of immunization were destroyed by simultaneous treatment with an immunostimulant.

Keywords: atherosclerosis, Immunization, liposome, ELISA, anticholesterol antibody



Back