30 October 1998
Involvement of the immunological and inflammatory response in the pathogenesis of neurodegenerative and ischemic diseasesMałgorzata Kohutnicka, Andrzej Członkowski, Anna Członkowska
Med Sci Monit 1998; 4(6): RA1096-1103 :: ID: 501942
This article is a review of current knowledge concerning the involvement of inflammatory response elements in the development of Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ischemia. There exists increasing evidence that inflammation may not be only a consequence of the already existing AD pathology but also may by involved in neuronal destruction. Many proteins associated with inflammation have been found within AD lesions. The complement system is one of the most important inflammatory factors that is supposed to play a role in the pathogenesis of AD. Activated glial cells are the most characteristic cellular components associated with pathological features (classical plaques, not diffuse plaques) in AD. It is suggested that microglial cells and astrocytes are sources of various cytokines that may influence the functioning of neurons as well as may contribute to the formation of amyloid plaques, thus play an important role in the pathogenesis of the disease. The suggestion that the inflammatory process is involved in the pathogenesis of AD has also been confirmed by clinical and epidemiological studies. Mechanisms which provoke the cells death in PD remain unknown. It is still a matter of controversy whether immune mechanisms are involved in the pathogenesis of neurodegeneration as the primary event generating a secondary cascade of changes leading to cell death, or their activation is a secondary reaction to the presence of the neurodegenerative process. Markers suggesting the presence of an inflammatory reaction were also observed within the nigrostriatal system of mice with experimental PD. It is possible that factors modifying the course of this experimental model neurodegenerative process may be useful therapeutic agents in the treatment of idiopathic PD. There is increasing evidence suggesting that the inflammatory response plays an important role during CNS ischemic injury. Understanding how leucocytes traffic to the brain injured ischemic tissue has led to the development of potential new treatment interventions of this pathological state.
Keywords: immunological system, Alzheimer Disease, Parkinson, Amyotrophic Lateral Sclerosis, cerebral ischemia
This Week Editorial
20 September 2021 : EditorialEditorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19
Med Sci Monit 2021; 27:e934766
22 September 2021 : EditorialEditorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...
Med Sci Monit In Press; DOI: 10.12659/MSM.934854
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
24 Sep 2021 : Clinical ResearchA Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...
Med Sci Monit In Press; DOI: 10.12659/MSM.933809
24 Sep 2021 : Database AnalysisRelationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)
Med Sci Monit In Press; DOI: 10.12659/MSM.933448
24 Sep 2021 : Database AnalysisA Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors
Med Sci Monit In Press; DOI: 10.12659/MSM.933559
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700