03 November 1997
Basal serum concentration of selected enterohormones and pancreatic hormones in patients with Turner's syndromeWojciech K. Cichy, Marian Krawczyński, Jerzy Smorawiński
Med Sci Monit 1997; 3(6): CR826-830 :: ID: 501789
Background: Turner syndrome (Ts) is a natural model for the analysis of insufficient function of the ovaries on the operation of other organs, e. g. pancreas, intestine or stomach. Ts patients demonstrated a more frequent occurrence of impaired carbohydrate metabolism, and its pathogenesis has not been fully explained yet. Theoretical data imply that the change of entero-pancreatic axis activity may play a role in this phenomenon. The aim of the study was to explain the influence of selected enterohormones (EH) and pancreatic hormones (PH) on the condition of systemic dyshormonism as well as to define the role of these hormones in the maintenance of carbohydrate homeostasis (taking into consideration their influence upon potential diabetes occurrence) in Ts patients.
Results/Conclusions: 1. The changes in the profiles of basal serum concentrations of enterohormones (IG, GIP) and pancreatic hormones (IRI, CRP, PP) confirm their part in the regulation of impaired carbohydrate metabolism which occurs in patients without oestrogenic function of the gonads in the course of Turner syndrome. 2. The decreased incretin function of entero-pancreatic axis, preceding the occurrence of diabetes, may be responsible for the impairment of carbohydrate metabolism which develops with Ts patients' age.
Material/Methods:The study included 13 patients with Turner syndrome, with 45, X karyotype, aged 4-23. Radioimmunoassay (RIA) was applied in order to determine basal serum concentrations of selected PH (IRI, CRP, PP) and EH (IG and GP).
Keywords: Turner, glucose tolerance, entero-pancreatic axis, enterohormones
27 September 2021 : EditorialEditorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic Monoclonal Antibody for Advanced Non-Small Cell Lung Cancer (NSCLC)
Med Sci Monit 2021; 27:e934854
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
09 July 2021 : Database AnalysisA Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...
Med Sci Monit In Press; DOI: 10.12659/MSM.931467
27 Sep 2021 : Clinical ResearchEffect of Combined Thoracic Paravertebral Block and General Anesthesia vs General Anesthesia Alone on Posto...
Med Sci Monit In Press; DOI: 10.12659/MSM.933623
24 Sep 2021 : Clinical ResearchA Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...
Med Sci Monit In Press; DOI: 10.12659/MSM.933809
24 Sep 2021 : Database AnalysisRelationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)
Med Sci Monit In Press; DOI: 10.12659/MSM.933448
Most Viewed Current Articles
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700