Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1997

Comparative evaluation of commonly used in vitro tests in screening of thyroid function

Dariusz Sitkiewicz, Maria F. Puławska, Jadwiga Janas, Dariusz Pączkowski, Ewa Matraszak

Med Sci Monit 1997; 3(4): PI594-598 :: ID: 501456

Abstract

In view of the increasing number of in vitro tests of thyroid function standardization of the biochemical assessment of patients with suspected thyroid disease was attempted. In 145 patients, measurements were made of serum total triiodothyronine (T3), tyroxine (T4) and thyrotropin (TSH) by the highly sensitive methods using the Delfia system. For comparative purposes, Delfia results were compared with those obtained by three different immunoassays: RIA, LIA and FPIA. The correlation between all tested methods over a wide range of concentrations was good, indicating very close agreement in the ranking of results. Correlation coefficients in all cases were higher than 0.90 and the intercepts did not differ significantly from zero. On the basis of the obtained results, the sensitivity, specificity and diagnostic power of the total T3, total T4 and TSH measurements for discrimination between euthyroid, hypothyroid and hyperthyroid patients was determined. TSH assay showed the highest sensitivity and diagnostic power as compared to total T3 and T4 assays. A significant, negative correlation was found in all studied patients population between TSH and T3 and TSH and T4 (r = -0.564 and r -0.695 respectively). These results seems to suggest that: 1) a detectable, normal TSH level indicates that the patient is euthyroid, and 2) a raised or lowered TSH level should be followed by measurement of T4 rather than T3 to distinguish between euthyroism and hypothyroidism and hyperthyroidism. This study also suggests that for practical purposes the best single screening test of thyroid function is TSH measured with a sensitive immunometric assay.

Keywords: Thyroid function, in vitro thyroid testing, immunoassays

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750