01 July 1997
Life-saving therapy with alfa-2b interferon in an infant with Kasabach-Merritt syndrome
Mariusz Wysocki, Ewa Masłowska, Irena Drapińska, Danuta Kurylak, Anna Balcar-BorońMed Sci Monit 1997; 3(4): CS584-588 :: ID: 501439
Abstract
The study describes the case of a male infant with giant hemangioma (localised on the head, neck and upper part of thorax) with highly progressive, life-threatening symptoms of disseminated intravascular coagulation and superior vena cava syndrome. Due to lack of improvement after initial treatment with large doses of corticosteroids and deficient haemostatic factor substitution, we used interferon alfa-2b treatment in everyday doses of 3 mlnU/m2,/day. After a week of treatment, the general condition of the patient improved, the severity of symptoms of superior vena cava syndrome decreased. The hemangioma was progressively decreasing, the haemostasis parameters were returning to normal values (their full normalisation was obtained after 4 months of treatment). In the fifth month, hemangioma transiently increased its diameters and signs of disseminated intravascular coagulation returned, so the dose of interferon was transiently increased. Interferon treatment was applied for the total of 12 months, resulting in very good clinical outcome without major side effects. The case described here confirms that treatment with interferon alfa creates new therapeutic possibilities in situations regarded so far as hopeless.
Keywords: giant hemangioma, Kasabach-Merritt syndrome, treatment, interferon alfa
Editorial
01 May 2022 : Editorial
Editorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19DOI: 10.12659/MSM.937048
Med Sci Monit 2022; 28:e937048
SARS-CoV-2/COVID-19
16 May 2022 : Clinical Research
Importance of Influenza Anti-Hemagglutinin Antibodies During the SARS-CoV-2 Pandemic in the 2019/2020 Epide...Med Sci Monit In Press; DOI: 10.12659/MSM.936495
04 May 2022 : Clinical Research
Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...Med Sci Monit In Press; DOI: 10.12659/MSM.936069
22 April 2022 : Clinical Research
Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)Med Sci Monit In Press; DOI: 10.12659/MSM.936547
27 April 2022 : Meta-Analysis
Effect of the COVID-19 Pandemic on Serum Vitamin D Levels in People Under Age 18 Years: A Systematic Review...Med Sci Monit In Press; DOI: 10.12659/MSM.935823
In Press
18 May 2022 : Clinical Research
Physical and Psychosocial Concept Domains Related to Health-Related Quality of Life (HRQL) in 50 Girls and ...Med Sci Monit In Press; DOI: 10.12659/MSM.936801
18 May 2022 : Clinical Research
Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Haina...Med Sci Monit In Press; DOI: 10.12659/MSM.936134
17 May 2022 : Clinical Research
Clinical Application of C-TIRADS Category and Contrast-Enhanced Ultrasound in Differential Diagnosis of Sol...Med Sci Monit In Press; DOI: 10.12659/MSM.936368
17 May 2022 : Laboratory Research
Artificial Dermal Scaffold Loaded with Platelet-Rich Plasma Promotes Wound Healing in Pigs by Favoring Angi...Med Sci Monit In Press; DOI: 10.12659/MSM.936186
Most Viewed Current Articles
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review article
Long-Term Respiratory and Neurological Sequelae of COVID-19DOI :10.12659/MSM.928996
Med Sci Monit 2020; 26:e928996
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952