01 July 1997
Colorectal carcinoma in patients under 40 years of age: clinical presentation and early effects of treatmentKrzysztof Bielecki, Piotr Kamiński, Mirosław Klukowski, Andrzej W Włodarczyk
Med Sci Monit 1997; 3(4): CR499-503 :: ID: 501343
During the years 1988 to 1995, 327 patients were treated for primary colorectal carcinoma; 15 (5.4%) of them (11 women, 4 men) were 26-40 years old, with a mean age of 30.8 years. The majority of tumors, 11 (73.3%) were found in the left colon. This group was retrospectively compared with the remaining 312 patients in order to find out whether there were any differences in clinical presentation and early effects of the treatment. Carcinoma of the transverse colon was more frequent in young adults (20%) than in patients over 40 years of age (5.7%). This difference was statistically significant. In one patient carcinoma occurred secondary to ulcerative colitis of a 10-year duration. In the remaining patients the time from the onset of symptoms and diagnosis of the disease to surgical treatment ranged from 2 weeks to 18 months (mean time=6.5 months). All patients received surgical treatment. Two (2) women were operated urgently because of an ileus. Fourteen (14) patients underwent resection procedures, most frequently anterior rectal amputation. Intestinal anastomosis was not performed in 3 adults. Ten (10) patients received surgical procedure as a definitive treatment. Postoperative complications occurred in 5 (33.3%) adults. None of the patients died. Most patients (60%) had carcinoma of C and D stages of progression according to the modified Dukes classification; there was a similar incidence of advanced carcinoma in older patients (56.4%). Poorly differentiated adenocarcinoma (33.3%) and mucinous carcinoma (20%) were more frequent in younger than older patients (16.9% and 5.4%, respectively). The difference in the occurrence of mucinous carcinoma was statistically significant. On the basis of our data, we may conclude that there are no significant differences in the clinical picture and natural history of colorectal carcinoma in patients of these two groups apart from a more frequent occurrence of mucinous carcinoma in young patients.
Keywords: large intestine, Adenocarcinoma, mucinous carcinoma, carcinoma in young patients
01 December 2021 : EditorialEditorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19
Med Sci Monit 2021; 27:e935624
03 December 2021 : Laboratory ResearchInfluenza and Influenza-Like Respiratory Virus Infections in Children During the 2019/20 Influenza Season a...
Med Sci Monit In Press; DOI: 10.12659/MSM.934862
08 November 2021 : Database AnalysisVirtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Cor...
Med Sci Monit In Press; DOI: 10.12659/MSM.934102
01 November 2021 : EditorialEditorial: What Can be Learned from National and International Vaccine Adverse Event Reporting Systems Duri...
Med Sci Monit 2022; 28:e935299
07 Dec 2021 : Review articleA Review of the Impact of Neutrophils and Neutrophil Extracellular Traps (NETs) on the Development of Aorti...
Med Sci Monit In Press; DOI: 10.12659/MSM.935134
07 Dec 2021 : Review articleAdie’s Pupil: A Diagnostic Challenge for the Physician
Med Sci Monit In Press; DOI: 10.12659/MSM.934657
06 Dec 2021 : Animal ResearchAstragalus Flavone Induces Proliferation and Differentiation of Neural Stem Cells in a Cerebral Infarction ...
Med Sci Monit In Press; DOI: 10.12659/MSM.933830
Most Viewed Current Articles
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700