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01 July 1997

Reduction of apoptosis of in vitro cultured peripheral blood lymphocytes of HIV positive individuals by thymocartin

BeŽla Szende, Attila Horva‡th, Ka‡roly Nagy, J—ozsef Bocsi, Ilona Kovalszky, ƒEva Barab‡as

Med Sci Monit 1997; 3(4): BR456-459 :: ID: 501321

Abstract

Background: Apoptotic (natural or programmed) cell death of lymphocytes contributes to an immune decline of HIV-infected persons. Active fragments of thymopoietin may reduce apoptosis and slow down this progress of immune decline.
Material/Methods: In vitro studies were performed in order to investigate the apoptosis-reducing effect of a new active thymopoietin fragment, Thymocartin (Arg-Lys-Asp-Val). Separated peripheral blood lymphocytes of 10 asymptomatic HIV-positive and 7 HIV-negative persons were cultured. Unstimulated, IL-2-stimulated and IL-2-stimulated plus 0.1 and 0.001 µg/ml Thymocartin-treated cells were investigated for apoptosis by morphological (HE, Apop-Tag), flow cytometric and agarose DNA fragmentation methods.
Results: Unstimulated lymphocytes of HIV-positive persons showed higher apoptotic activity than those of HIV-negative persons. IL-2-stimulation increased the apoptotic rate in 7 HIV-positive and 1 HIV-negative individuals. Thymocartin reduced the apoptotic activity in 8 HIV-positive and 1 HIV-negative case.
Conclusions: Thymocartin reduces the apoptotic activity in lymphocytes of HIV-positive patients in vitro. This compound may have the same effect in vivo and may prolong the asymptomatic period of HIV-infected patients.

Keywords: HIV-infection, thymocartin

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750