High resolution 1H NMR spectroscopy of human cerebrospinal-fluid: a preliminary study

Normal cerebrospinal fluid (CSF) sample and CSF samples from patients with neuropathology were tested using high-resolution 1D nuclear magnetic resonance proton spectroscopy. Several metabolites and changes in their concentration were observed. Analyses of concentration of lactic acid cycle substances and aminoacids were performed. For one patient we observed a higher metabolic level. Spin-lattice relaxation time (T1) measurement and calculations were done. No significant changes in the T1 value were observed.

Keywords: high-resolution proton NMR spectroscopy, Cerebrospinal Fluid