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eISSN: 1643-3750

Lymphocyte sodium efflux and serum level of cyclic AMP in patients with ventricular arrhythmias

Wojciech Kosmala

Med Sci Monit 1996; 2(2): HY227-232

ID: 499756

Published: 1996-03-01


Disorders in ionic transport across the cell membrane of cardiomyocytes leading to abnormalities in the impulse generation and propagation may be a cause of ventricular dysrhythmia. The adenosine triphosphatase-dependent sodium-potassium pump (Na+ K+,-ATPase) and cyclic adenosine monophosphate (cAMP) play an important role in this transport. Na+, K+,-ATPase is responsible for extrusion of three sodium cations from the cell in exchange for two potassium cations brought into the cytosol, thus creating a negative membrane potential. The part played by cAMP in the transmembrane ionic transport consists of, essentially, an increase in calcium influx into the cell and, to a lesser extent, potassium and a decrease in sodium influx, as a result of the phosphorylation of appropriate ion channels catalyzed by protein kinase.

Keywords: K+ -adenosine triphosphatase, cyclic adenosine monophosphate, Propafenone, metoprolol, amiodarone, Na+, ventricular arrhythmias



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