01 March 1996
Diffuse intermyocardiocytic fibrosis in patietns with chronic renal failure - a histomorphometric study
Marian Danielewicz, Małgorzata Wągrowska-Danielewicz, Ewa RutkowskaMed Sci Monit 1996; 2(2): BR163-167 :: ID: 499555
Abstract
In 57 uraemic patients with end-stage renal diseases intermyo-cariocytic fibrosis was quantitatively evaluated at postmortem examination. The patients were divided into four groups: group A included 20 hypertensive patients with chronic glomerulonephritis, group B included 17 patients with diabetic nephropathy, group C included 10 hypertensive patients with renal amyloidosis group D included 10 nonhypertensive patients with renal amyloidosis. Patients with stenosing coronary lesions were excluded from the study. 20 specimens of heart tissue from non uraemic patients without coronary stenosis were used as a control group. Histological morphometry was performed by means of an image analysis system. The examination showed that diffuse non-coronary intermy-ocardiocytic fibrosis was significantly higher (approximately threefold) in all groups of uraemic patients in comparison with the controls. Significant differences were also found between uraemic hypertensive and nonhypertensive patients. However, they were not observed among groups A, B, and C. Strong correlations were noted between interstitial myocardial fibrosis and duration of renal failure as well as between interstitial myocardial fibrosis and serum creatinine level. The authors believe that diffuse non-coronary intermyoca-rdiocytic fibrosis is a morphological feature of uraemia, however, it is independent of the cause of renal failure. Hypertension has also been found to be an additional causative factor of interstitial myocardial fibrosis.
Keywords: intermyocardiocytic fibrosis, chronic renal failure
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952