Elevated circulating transforming growth factor β-1 may explain poorer renal survival in type II diabetics with chronic hepatitis C

Hepatitis C is reported to be associated with poorer renal survival in patients with diabetes. The mechanism for this observation has not been elucidated. Transforming growth factor β-1 is involved in signaling for human disease involving fi brosis and excess matrix deposition including diabetic nephropathy. Hepatitis C virus core protein is known to upregulate transcription of TGF β-1 in the liver and HCV patients have elevated levels of circulating TGF β-1 versus controls. There is evidence that elevated circulating TGF β-1 levels result in more rapid progression of nephropathy and that lowering circulating TGF β-1 levels with an angiotensin converting enzyme inhibitor correlates with treatment effi cacy in diabetic nephropathy. This paper outlines a hypothesis that the elevated level of circulating TGF β-1 which is associated with HCV is a mediator of more rapid progression of diabetic renal disease in persons with HCV.

Keywords: Diabetes Mellitus, Type 2 - physiopathology, Comorbidity, Diabetic Nephropathies - physiopathology, Disease Progression, Hepatitis C, Chronic - physiopathology, Signal Transduction - physiology, Transforming Growth Factor beta1 - metabolism