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30 January 2007

Role of SPARC-matricellular protein in pathophysiology and tissue injury healing: Implications for gastritis and gastric ulcers

Emily Phan, Amrita Ahluwalia, Andrzej S. Tarnawski

Med Sci Monit 2007; 13(2): RA25-30 :: ID: 473774

Abstract

In this paper we reviewed roles of SPARC in cell functions with a focus on tissue injury healing. SPARC (Secreted Protein, Acidic and Rich in Cysteine) is a matrix-associated glycoprotein that influences a variety of cellular activities in vitro and in vivo. SPARC and its related peptides bind to several proteins of the extracellular matrix (ECM), affect ECM protein expression, alter cell shape, reduce cellular adhesion, influence migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC influences cell interactions with the extracellular milieu during embryonic development and in response to tissue injury. This paper reviews the roles of SPARC in the cellular and molecular events taking place during healing of tissue injury. We also present preliminary data on increased SPARC expression in gastritis and in granulation tissue of human gastric ulcer.

Keywords: Cell Movement - physiology, Cell Adhesion - physiology, Cell Shape - physiology, Extracellular Matrix - physiology, Gastritis - physiopathology, Granulation Tissue - physiopathology, Models, Molecular, Neovascularization, Physiologic, Osteonectin - physiology, Stomach Ulcer - physiopathology, Wound Healing - physiology

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Medical Science Monitor eISSN: 1643-3750
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