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30 January 2007

A case of cerebral amyloid angiopathy

Richard Felwick, Khaled Amar

Med Sci Monit 2007; 13(2): CS24-26 :: ID: 473771

Abstract

Background: Cerebral amyloid angiopathy (CAA) is a condition characterized by amyloid deposition in the walls of leptomeningal and cerebral cortical blood vessels. Clinically, CAA results in recurrent lobar haemorrhage that frequently presents with cognitive impairment or recurrent cerebral ischaemic
events. CAA is widely believed to be under-diagnosed.
Case Report: An 84 year old patient presented with a history of recurrent unexplained collapses on a background of cognitive impairment. CT imaging of the brain demonstrated several lobar haemorrhages. In the absence of other causes of cerebral haemorrhage, the patient fulfi lled the Boston diagnosis
criteria for probable CAA.
Conclusions: CAA should be considered in patients with multiple lobar haemorrhages, especially in the presence of cognitive impairment, and in the absence of other causes of cerebral haemorrhage such as trauma, space occupying lesion or a coagulopathy. The diagnosis of CAA is an important one
because of the likely implication it has on future management targeted to reducing the future risk of further bleeding.

Keywords: Aged, 80 and over, Cerebral Amyloid Angiopathy - psychology, Cerebral Hemorrhage - etiology, Cognition Disorders - etiology, Tomography, X-Ray Computed

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