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01 November 2007

A Simplified Premedication Protocol for One-Hour Paclitaxel Infusion in Various Combinations

Christos Kosmas, Nicolas Tsavaris

Med Sci Monit 2006; 12(11): CR462-466 :: ID: 462697

Abstract

BACKGROUND: Many investigations have focused on optimal doses/schedules since regulatory agency approval of paclitaxel (Taxol). Paclitaxel is generally administered at doses of 175–225 mg/m[sup]2[/sup] over 3 hours or 135–175 mg/m[sup]2[/sup] over 24 hours, every 3 weeks. The purpose of this study was to simplify administration

MATERIAL/METHODS: One hundred patients who were to receive paclitaxel-based chemotherapy combinations entered the study. Tumor types were non-small-cell lung cancer (NSCLC, n=40), small-cell lung cancer (SCLC, n=18), breast cancer (n=12), head and neck cancer (n=16), and ovarian cancer (n=14). Sixty patients received paclitaxel at 175 mg/m[sup]2[/sup] and the remaining 40 at 225 mg/m[sup]2[/sup]. The premedication regimen consisted of a single dose of dexamethasone 20 mg, dimethindene maleate (Fenistil)

RESULTS: Hypersensitivity reactions were recorded in 7 patients (7.0%) and were not infl uenced by age, gender, disease, dose schedule, or cycles of therapy. No serious adverse events were observed.

CONCLUSIONS: The simplifi ed administration dose schedule for paclitaxel is safe and accommodates its combination with other cytostatic agents.

Keywords: Antineoplastic Agents, Phytogenic - administration & dosage, Adult, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Dexamethasone - administration & dosage, Dimethindene - administration & dosage, Neoplasms - drug therapy, Paclitaxel - administration & dosage, Premedication, Ranitidine - administration & dosage, Time Factors

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