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01 November 2006

The effectiveness of an extracellular low-potassium solution in 24-hour lung graft preservation

Panagiotis Dedeilias, Efstratios Koletsis, Efstratios Apostolakis, Maria Chorti, Barbara Sfyra, Apostolos Papalois, Ion Bellenis, Konstantin Bolos

Med Sci Monit 2006; 12(11): BR355-361 :: ID: 462567

Abstract

Background: The transplanted lung suffers ischemia-reperfusion injury and many efforts have been made to improve preservation. The aim of this study was to compare the effectiveness of intracellular high-potassium Belzer solution versus extracellular Celsior in 24-hour lung preservation.
Material/Methods: Sixteen pigs weighing 25.1–28.1 kg underwent single, left-lung allotransplantation. Sixteen other pigs were donors of the left lung. Heart and lungs were retrieved from the donors using single- fl ush perfusion by a randomly selected solution that was also used for cold storage (4°C) for
24 hrs. Biopsies were taken from the right lung before storage, after the preservation, and fi nally
three hours following transplantation. The observation period lasted three hours following transplantation.
Results: Pulmonary artery pressure and pulmonary vascular resistance were signifi cantly higher in the
Belzer group (p

Keywords: Insulin - pharmacology, Time Factors, Temperature, Swine, Reperfusion Injury, Raffinose - pharmacology, Pulmonary Artery - metabolism, Potassium - pharmacology, Organ Preservation Solutions - pharmacology, Mannitol - pharmacology, Lung Transplantation - methods, Lung - pathology, Animals, Histidine - pharmacology, Graft Survival, Glutathione - pharmacology, Glutamates - pharmacology, Electrolytes - pharmacology, Disaccharides - pharmacology, Blood Pressure, Adenosine - pharmacology, Allopurinol - pharmacology, Anesthesia

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750