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Validity of plasma fibrinogen, D-dimer, and the von Willebrand factor as markers of cardiovascular morbidity in patients on chronic hemodialysis.

Dimitrios Kirmizis, Apostolos Tsiandoulas, Maria Pangalou, Evangelia Koutoupa, Paraskevi Rozi, Maria Protopappa, Konstantinos Barboutis

Med Sci Monit 2006; 12(2): CR55-62

ID: 445237

Available online: 2006-02-01

Published: 2006-02-01

Background: Among the non-classic cardiovascular disease risk factors inend-stage renal disease patients on chronic hemodialysis (HD), plasma fibrinogen, D-dimer, and von Willebrandfactor (vWf) levels are potential markers of cardiovascular morbidity. We designed this case-controlstudy to investigate their validity and any differences between them. Material/Methods: Twenty-five HDpatients (18 males, mean age: 63, range: 52-69 years) comprised the group with prevalent cardiovasculardisease (CVD) and 50 HD patients (35 males, mean age: 62, range: 40-77 years) with non-evident cardiovasculardisease history constituted the second study group. Twenty-five healthy non-smoking volunteers servedas controls for comparison with the study groups. Results: Patients with CVD had significantly higherconcentrations of plasma fibrinogen, D-dimer, and vWf than patients without incident CVD. All three parameterscorrelated positively with cardiovascular morbidity, i.e. fibrinogen (r=0.378, P0.001), logDD (r=0.70,P

Keywords: Cardiovascular Diseases - etiology, Biological Markers - blood, Adult, Case-Control Studies, Fibrin Fibrinogen Degradation Products - metabolism, Fibrinogen - metabolism, Kidney Failure, Chronic - therapy, Odds Ratio, Renal Dialysis, Reproducibility of Results, von Willebrand Factor - metabolism