Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

01 December 2005

IgG subclass antibody response to mycobacterial serine protease at differentstages of pulmonary tuberculosis.

Sonika Gupta, Niraj Shende, Amarjeet Bhatia, Satish Kumar, Bhaskar Harinath

Med Sci Monit 2005; 11(12): CR585-588 :: ID: 438856

Abstract

Background: Tuberculosis (TB) is a chronic bacterial infection caused by M. Tuberculosis. Studies of antibody response in TB have focussed mainly on their usefulness as a diagnosticserological tool, with little attention given to analysis of antibodies at the isotype and subclass levelin relation to disease pathogenesis. Hence the present study was done to analyse IgG subclass responseat different stages of tuberculosis, in order to understand the immunological events associated withdisease development. Material/Methods: Sera samples were collected from 104 subjects: 79 tuberculosispatients (fresh, relapse and chronic cases) and 25 healthy normals. IgG subclass antibody response wasanalysed by indirect plate peroxidase ELISA against previously reported mycobacterial serine protease(ES-31) antigen. Results: Fresh cases of tuberculosis showed increased IgG1 and IgG3 antibodies, whilea few cases showed moderately increased IgG2. IgG1 and IgG3 were found to be elevated with increasedbacillary load. Relapse and chronic cases showed increased IgG1 and IgG3, while positivity to IgG2 wasdecreased. Chronic cases showed a moderate increase in IgG4 antibody. Thus IgG1 and IgG3 were predominantin all forms of tuberculosis. Conclusions: The elevated levels of IgG1 and IgG3 antibodies to mycobacterialserine protease in active tuberculosis observed in this study provide an additional marker for diagnosisof tuberculosis. Furthermore, the higher level of these antibodies with high bacillary load patientsand in chronic cases of tuberculosis may provide valuable insight into their possible role in diseaseprogression.

Keywords: Antibody Formation, Antibodies, Bacterial - blood, Biological Markers, Disease Progression, Immunoglobulin G - blood, Mycobacterium tuberculosis - immunology, Serine Endopeptidases - immunology, Tuberculosis, Pulmonary - diagnosis

0 Comments

This Week Editorial

13 September 2021 : Editorial

Editorial: The First Monoclonal Antibody Vaccine to Prevent Malaria Heralds a New Era of Malaria Vaccines to the Plasmodium falciparum Circumsporozoite Protein (PfCSP)

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934676

Med Sci Monit 2021; 27:e934676

Coronavirus/Covid 19

15 September 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of...

Med Sci Monit In Press; DOI: 10.12659/MSM.934766  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

15 Sep 2021 : Clinical Research

Polish Medical Air Rescue Interventions Concerning Pregnant Women in Poland: A 10-year Retrospective Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.933029  

15 Sep 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of...

Med Sci Monit In Press; DOI: 10.12659/MSM.934766  

15 Sep 2021 : Clinical Research

A Prospective Single-Center Study of the Effects of Repetitive Transcranial Magnetic Stimulation at 2-Week ...

Med Sci Monit In Press; DOI: 10.12659/MSM.933017  

15 Sep 2021 : Clinical Research

Computed Tomography-Guided Radiofrequency Ablation of the Cervical Dorsal Root Ganglia in 27 Patients with ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932612  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750