Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 October 2005

Ambulatory blood pressure, sympathetic activity, and left ventricular structureand function in middle-aged normotensive men with exaggerated blood pressure response to exercise.

Nobuyuki Miyai, Mikio Arita, Ikuharu Morioka, Shintaro Takeda, Kazuhisa Miyashita

Med Sci Monit 2005; 11(10): CR478-484 :: ID: 430309

Abstract

BACKGROUND: It is claimed that exaggerated blood pressure (BP) reactivityto behavioral stress may play a role in hypertension. This study aimed to clarify whether exaggeratedBP reactivity during physical exercise is associated with any other abnormalities in ambulatory BP, autonomicnervous control, and target organ damage among middle-aged normotensive men. MATERIAL/METHODS: A totalof 54 sedentary men (39+/-4 years old) with normal BP were enrolled in this study. Twenty-seven withexaggerated BP reactivity to exercise (ER) were compared with 27 age-matched controls with normal BPreactivity (NR). The subjects underwent 24-hour ambulatory BP monitoring, short-term Finapres recordings,a bicycle ergometry test, and M-mode and pulsed-Doppler echocardiography. RESULTS: The ambulatory BPmeasurements were significantly higher in the ER group than in the NR group averaged over a 24-hour period,during daytime and nighttime. Power spectral analysis from continuous Finapres data revealed increasedsystolic BP variability in the low frequency band in the ER group. During graded exercise, the ER groupshowed remarkable elevations in systolic and diastolic BP compared to the NR group without a differencein heart rate increments. Although the plasma epinephrine showed similar levels, yet the exercise-inducedincrease in plasma norepinephrine in the ER group was significantly greater than in the NR group. Inechocardiographic dimensions, left ventricular internal diameter and mass index were not different, whereasthe ER group presented significantly greater posterior wall thickness. Doppler functional data showedsignificant increase in the late to early flow velocity ratio in the ER group. CONCLUSIONS: Even in theabsence of hypertension, exaggerated BP reactivity to physical exercise suggests greater BP elevationduring daily activity as well as enhanced sympathetic nervous tonus, which may be considered a risk factorpromoting hypertension, and these hemodynamic and neurohumoral behaviors are associated with a tendencyto develop target organ abnormalities in the heart.

Keywords: Cross-Sectional Studies, Blood Pressure, Echocardiography, Exercise - physiology, Exercise Test, Heart Ventricles - anatomy & histology, Sympathetic Nervous System - physiology, Ventricular Function

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750