Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

01 October 2005

Ambulatory blood pressure, sympathetic activity, and left ventricular structureand function in middle-aged normotensive men with exaggerated blood pressure response to exercise.

Nobuyuki Miyai, Mikio Arita, Ikuharu Morioka, Shintaro Takeda, Kazuhisa Miyashita

Med Sci Monit 2005; 11(10): CR478-484 :: ID: 430309

Abstract

BACKGROUND: It is claimed that exaggerated blood pressure (BP) reactivityto behavioral stress may play a role in hypertension. This study aimed to clarify whether exaggeratedBP reactivity during physical exercise is associated with any other abnormalities in ambulatory BP, autonomicnervous control, and target organ damage among middle-aged normotensive men. MATERIAL/METHODS: A totalof 54 sedentary men (39+/-4 years old) with normal BP were enrolled in this study. Twenty-seven withexaggerated BP reactivity to exercise (ER) were compared with 27 age-matched controls with normal BPreactivity (NR). The subjects underwent 24-hour ambulatory BP monitoring, short-term Finapres recordings,a bicycle ergometry test, and M-mode and pulsed-Doppler echocardiography. RESULTS: The ambulatory BPmeasurements were significantly higher in the ER group than in the NR group averaged over a 24-hour period,during daytime and nighttime. Power spectral analysis from continuous Finapres data revealed increasedsystolic BP variability in the low frequency band in the ER group. During graded exercise, the ER groupshowed remarkable elevations in systolic and diastolic BP compared to the NR group without a differencein heart rate increments. Although the plasma epinephrine showed similar levels, yet the exercise-inducedincrease in plasma norepinephrine in the ER group was significantly greater than in the NR group. Inechocardiographic dimensions, left ventricular internal diameter and mass index were not different, whereasthe ER group presented significantly greater posterior wall thickness. Doppler functional data showedsignificant increase in the late to early flow velocity ratio in the ER group. CONCLUSIONS: Even in theabsence of hypertension, exaggerated BP reactivity to physical exercise suggests greater BP elevationduring daily activity as well as enhanced sympathetic nervous tonus, which may be considered a risk factorpromoting hypertension, and these hemodynamic and neurohumoral behaviors are associated with a tendencyto develop target organ abnormalities in the heart.

Keywords: Cross-Sectional Studies, Blood Pressure, Adult, Echocardiography, Exercise - physiology, Exercise Test, Heart Ventricles - anatomy & histology, Sympathetic Nervous System - physiology, Ventricular Function

0 Comments

This Week Editorial

13 September 2021 : Editorial

Editorial: The First Monoclonal Antibody Vaccine to Prevent Malaria Heralds a New Era of Malaria Vaccines to the Plasmodium falciparum Circumsporozoite Protein (PfCSP)

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934676

Med Sci Monit 2021; 27:e934676

Coronavirus/Covid 19

15 September 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of...

Med Sci Monit In Press; DOI: 10.12659/MSM.934766  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

15 Sep 2021 : Clinical Research

Polish Medical Air Rescue Interventions Concerning Pregnant Women in Poland: A 10-year Retrospective Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.933029  

15 Sep 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of...

Med Sci Monit In Press; DOI: 10.12659/MSM.934766  

15 Sep 2021 : Clinical Research

A Prospective Single-Center Study of the Effects of Repetitive Transcranial Magnetic Stimulation at 2-Week ...

Med Sci Monit In Press; DOI: 10.12659/MSM.933017  

15 Sep 2021 : Clinical Research

Computed Tomography-Guided Radiofrequency Ablation of the Cervical Dorsal Root Ganglia in 27 Patients with ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932612  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750