Role of respiratory syncytial virus In respiratory tract infections pathogenesis in infants and small children
Grażyna Łuczak, Ewa Kozielska, Joanna Tyl, Anna Borkowska, Anna Galińska, Wojciech Radys, Zbigniew Bohdan
Med Sci Monit 2003; 9(4): 44-47
Background: Respiratory Syncytial Virus (RSV) is a common etiological agent of respiratory infections in neonates and small chil-dren.The aim of the study was to evaluate: frequency and clinical outcome of RSV infections in children, risk factors and coincidence with atopy and humoral immunodeficiency. Material/Methods: Patient ’s history, changes on physical examination, laboratory investigation, chest x-ray, serum IgA, IgG, IgM, IgE levels and specific IgM and IgG antibodies against RSV were analysed in 160 children, aged 2 to 36 months, with respiratory infection.Results: RSV infection was diagnosed on the basis of specific anti-RSV IgM antibodies appearance or increasing anti-RSV IgG level. The group of 61 children with RSV infection included: 13 (21.3%) premature infants, 14 (22.7%) children less than 2 months old and 32 (52.3%) patients over 12 months of age. The main clinical manifestations were: wheezing (obturative) bronchitis (75.4%), pneumonia (44.3%) or both (32.8%). Eight cases of severe bronchiolitis among the youngest infants were noted. Leukocytosis was observed in 77% and increased CRP level in 23% of children. Serum IgA and IgM levels were normal in 82%, IgG in 95.1% and total IgE level in 47.5% of patients. Increased IgE level was observed in 52.5%. Only 26.2% of these children demonstrated clinical features of atopy.Conclusions: RSV infection, usually obturative bronchitis or pneumonia,is commonly observed in young children. Severe bronchi-olitis may occur. Coincidence frequency of RSV infection with total serum IgE elevation and atopy needs further investigation.
Keywords: RSV, Respiratory Tract Infections, Immunoglobulins, children