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eISSN: 1643-3750

Vascular dementia and anticardiolipin antibodies.

José Maria Pereira de Godoy, Maria Regina Pereira de Godoy, José Paulo Cipulo, Valdir Antonio Tognola

Med Sci Monit 2005; 11(9): CR430-433

ID: 428451

Available online: 2005-09-01

Published: 2005-09-01


Background: An association between anticardiolipin antibodies and dementiahas been reported in several recent studies; however, its physiopathological mechanism remains controversial.The aim of this study was to evaluate the association of vascular dementia and anticardiolipin antibodies.Material/Methods: A random prospective investigation of 17 male and 13 female patients with vasculardementia was made with regard to anticardiolipin antibodies. Their ages ranged from 56 to 77 years (average:67.2 years). The criteria of NINDS-AIREN were used to define the vascular dementia. A control group of25 female and 9 male patients was formed with ages ranging from 62 to 80 years (mean: 68 years). Evaluationof the anticardiolipin antibodies was performed by means of Enzyme-Linked Immunoabsorbent Assay (ELISA)for the quantitative measurement of IgG and IgM antibodies against cardiolipins in serum. Statisticalanalysis was done using the Fisher's exact test, where p

Keywords: Antibodies, Anticardiolipin - blood, Case-Control Studies, Dementia, Vascular - immunology, Enzyme-Linked Immunosorbent Assay, Immunoglobulin G - blood, Immunoglobulin M - blood, Prospective Studies



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