Med Sci Monit 2000; 6(6): CS1182-1185 :: ID: 421204
The work presents 3 members of a family of 4, who were diagnosed to havecoeliac disease (one classic and two latent forms of the disease). Genetic investigation regarding allthree patients revealed the existence of HLA DQ A1*0501 allele associated with susceptibility to coeliacdisease. Due to a much more frequent occurrence of atypical forms of coeliac disease in family members,than in general population, and due to risks resulting from tardy diagnoses and the lack of treatment,it is recommended that patients should be subjected to tests determining the presence of antiendomysialantibodies, as well as to genetic investigation with regards to latent coeliac disease.
Keywords: Adolescent, Alleles, celiac disease, Child, Gluten, HLA-DQ Antigens, Immunoglobulin A, Intestinal Mucosa, Pedigree
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