31 December 1969
Med Sci Monit 2000; 6(6): RA1213-1222 :: ID: 421200
The blood brain barrier (BBB) is a highly dynamic structure and consistsof endothelial cells, which are characterized by the presence of tight junctions and relative lack ofendocytic vesicles. The tight junctions are reinforced by the foot processes of the astrocytes. The BBBfunctions through these specialised structures, to maintain the environment of the brain in a steadystate by regulating the influx and efflux of substances. The protective effect of the BBB is however,lost during bacterial and viral infections. The primary mechanism operative are an increase in the permeabilityof the BBB and/or direct invasion of the brain by microorganisms. Since the BBB is relatively impermeableto chemotherapeutic agents the treatment of CNS infections is difficult. This paper aims to examine thevarious mechanisms by which infection spreads to the brain, and suggest measures for successful drugdelivery into the brain during infections.
Keywords: Animals, Anti-Infective Agents, Biological Markers, Biological Transport, Active, Blood-Brain Barrier, Central Nervous System Infections, Models, Biological, Permeability, Pinocytosis, Tight Junctions
27 September 2021 : EditorialEditorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic Monoclonal Antibody for Advanced Non-Small Cell Lung Cancer (NSCLC)
Med Sci Monit 2021; 27:e934854
08 September 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit In Press; DOI: 10.12659/MSM.932788
16 July 2021 : Review articleSilent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.930776
09 July 2021 : Database AnalysisA Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...
Med Sci Monit In Press; DOI: 10.12659/MSM.931467
24 Sep 2021 : Clinical ResearchA Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in...
Med Sci Monit In Press; DOI: 10.12659/MSM.933809
24 Sep 2021 : Database AnalysisRelationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010-2021)
Med Sci Monit In Press; DOI: 10.12659/MSM.933448
24 Sep 2021 : Database AnalysisA Statistical Prediction Model for Survival After Kidney Transplantation from Deceased Donors
Med Sci Monit In Press; DOI: 10.12659/MSM.933559
Most Viewed Current Articles
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700