Sarel Halachmi, Ralph Madeb, Alexander Kravtsov, Boaz Moskovitz, Noami Halachmi, Ofer Nativ
Med Sci Monit 2001; 7(1): RA164-168
BACKGROUND: This article review the serial genetic changes which are responsibleto the initiation and progression of bladder cancer. Knowledge of the exact genetic alteration has adirect implication on the development of knew more sensitive and specific tool for an early diagnosisand better prognosis calculations.
CONCLUSION: Bladder cancer develop and progress through a series ofgenetic alterations. Understanding of the genetic mechanisms which lead to malignant transformation gaverise to the development of various genetic mechanisms which lead to malignant transformation gave riseto the development of various genetic tools providing better ability of early detection and more accurateprognosis prediction.
Keywords: bladder cancer, genetic alterations