Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

Effect of sevoflurane on intracranial pressure and cardiovascular functionin rabbits with experimental intracerebral haematoma.

Zbigniew Karwacki, Przemysław Kowiański, Janusz Moryś, Jerzy Dziewiątkowski, Ewa Kaczmarek, Janina Suchorzewska

Med Sci Monit 2001; 7(2): BR212-217 :: ID: 421161

Abstract

BACKGROUND: Sevoflurane is one of the newest volatile anaesthetic agents.The effect of sevoflurane on ICP in conditions of intracranial pathology is essential from the clinicalpoint of view but still not sufficiently clear. The aim of the study was to examine the effects of 1MAC, 2 MAC, 3 MAC sevoflurane on intracranial pressure (ICP), mean arterial blood pressure (MABP) andheart rate (HR) in rabbits with experimental intracerebral haematoma (ICH).
MATERIAL AND METHODS: Theexperiments were performed in 13 adult rabbits, 3.5-4.0 kg weight. The rabbits were randomly allocatedto two different groups. In group I, (n = 7), sevoflurane was administered in stepwise increasing concentrationsof 2.2 vol%, 4.4 vol% and 6.6 vol%, each for a period of 15 minutes. In group II (n = 6), intracerebralhaematoma was produced and subsequently sevoflurane was administered in the same manner as in group I.Ventilation parameters, inspiratory and end-tidal sevoflurane concentration, end-tidal CO2 concentration(ETCO2), HR, MABP, ICP and body temperature, measured in the nasopharynx, were monitored throughout theexperiment.
RESULTS: Mean values of ETCO2 and temperature in the nasopharynx were not significantly differentin both groups and remained stable in the whole observation period. In group II in all cases the evidenceof intraventricular haematoma was observed. In this group mean values of ICP, MABP and HR after haematomaproduction were significantly higher than those in group I. Statistically significant increase of ICPwas observed in 30th minute in group I, while in 35th minute in group II. In both groups a statisticallysignificant decrease in MABP was observed from 20th minute of observation. A significant decrease inHR in both groups from 25th minute of experiment was also observed.
CONCLUSION: In conclusion it shouldbe stressed that sevoflurane, in doses not exceeding 1 MAC, shows no significant effect on ICP and cardiovascularfunction in the course of intracranial haematoma.

Keywords: intracranial hemorrhage, Intracranial Pressure, rabbit, sevoflurane

0 Comments

Editorial

01 December 2021 : Editorial  

Editorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19

Dinah V. Parums
Scientific Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.935624

Med Sci Monit 2021; 27:e935624

SARS-CoV-2/COVID-19

03 December 2021 : Laboratory Research  

Influenza and Influenza-Like Respiratory Virus Infections in Children During the 2019/20 Influenza Season a...

Med Sci Monit In Press; DOI: 10.12659/MSM.934862  

08 November 2021 : Database Analysis  

Virtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Cor...

Med Sci Monit In Press; DOI: 10.12659/MSM.934102  

01 December 2021 : Editorial  

Editorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19

Med Sci Monit 2021; 27:e935624

In Press

03 Dec 2021 : Clinical Research  

A Retrospective Single-Center Study of 23 Patients to Compare Gait Before and After Total Hip Arthroplasty ...

Med Sci Monit In Press; DOI: 10.12659/MSM.934558  

03 Dec 2021 : Laboratory Research  

Influenza and Influenza-Like Respiratory Virus Infections in Children During the 2019/20 Influenza Season a...

Med Sci Monit In Press; DOI: 10.12659/MSM.934862  

02 Dec 2021 : Clinical Research  

Comparison of Outcomes Following Neuronavigation-Assisted Aspiration and Thrombolysis Using Single and Mult...

Med Sci Monit In Press; DOI: 10.12659/MSM.934935  

02 Dec 2021 : Clinical Research  

Serum Levels of N-Terminal Pro-Brain Natriuretic Peptide in Gestational Hypertension, Mild Preeclampsia, an...

Med Sci Monit In Press; DOI: 10.12659/MSM.934285  

Most Viewed Current Articles

20 Mar 2020 : Clinical Research  

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research  

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article  

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research  

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750