01 January 2001
My life and times with enzymes and mediators.
John R VaneMed Sci Monit 2001; 7(4): RA790-800 :: ID: 421066
Abstract
The vascular endothelium plays a vital role in the control of the circulation.It metabolises various vasoactive substances, converts angiotensin I to angiotensin II and secretes thepotent vasodilator prostacyclin, as well as nitric oxide and endothelin-1. The balance between thesemediators determines the response of the cardiovascular system in diseases such as hypertension, atherosclerosisand myocardial infarction. In this article I describe some of my work over the past 50 years. In theprocess, I hope to show that it is not only Princes who travel the road to Serendip but also Scientists.The application of simple methods, luck, happy coincidences, serendipity and noticing the unusual haveall played an important role in my scientific career. However, the choice of colleagues has also beenvital.
Keywords: blood bathed organs, endothelial cell, Pulmonary Circulation, Renin, snake venom peptides, ACE, Angiotensin I
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952