22 February 2002
Med Sci Monit 2002; 8(2): BR47-55 :: ID: 420947
BACKGROUND: In the present study we hypothesized that leptin-induced lipolyticeffects show depot-specific differences. MATERIAL/METHODS: Three-month-old male lean (+/+) and obesefa/fa rats were used. Lipolysis was determined in the absence or presence of leptin (0.63, 6.25 and 62.5nM) together with agents acting at the A1 adenosine receptor of fat cells isolated from both subcutaneousand omental depots. The glycerol released into the incubation medium was taken as the lipolytic rateindex. RESULTS: The highest dose of leptin produced a 57.5 +/- 7.3% and 70.3 +/- 3.8% increase in omentaland subcutaneous glycerol release, respectively, compared to the basal lipolytic rate (P<0.001).
CONCLUSION: It can be concluded that decreased sensitivity to the lipolytic effect of leptin in omental adipocytes compared to subcutaneous fat cells may underlie, at least in part, the association of visceral fat accumulation with increased co-morbidities.
Keywords: Adipocytes, Animals, Leptin, Lipolysis, Rats, Rats, Zucker, Receptors, Purinergic P1, Species Specificity, Virulence Factors, Bordetella
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