22 February 2002
Early cardiovascular involvement in patients with systemic sclerosis (SSc).
Marzenna Zielińska, Iwona Cygankiewicz, Jerzy Wranicz, Bozena Dziankowska-Bartkowiak, Anna Sysa-JedrzejowskaMed Sci Monit 2002; 8(2): CR78-82 :: ID: 420937
Abstract
BACKGROUND: Systemic sclerosis (SSc) is a connective tissue disease characterizedby progressive fibrosis of the skin, and by distinctive forms of internal organ involvement. Symptomsusually occur relatively late and are nonspecific, thus often unrecognized. The purpose of our studywas to evaluate cardiac function in patients with SSc by means of non-invasive methods in order to detectearly dysfunction of the cardiovascular system. MATERIAL/METHODS: A group of 22 patients with SSc wascompared with a group of 22 healthy volunteers. Standard EKG, 24-hour Holter monitoring (HM), and echocardiographywere performed in all subjects. RESULTS: In patients with SSc, HM revealed a tendency to tachycardia.Conduction disturbances were observed in 3 patients. In 6 patients significant ventricular arrhythmiawas found. Silent ischemia episodes were detected in 6 patients. In HRV analysis, significantly lowervalues were detected in patients with SSc than in controls. LPs were present in one patient with SSc,and none in the control group. The mean values for QT interval did not exceed the range of normal values.No signs of systolic cardiac dysfunction were detected, while in 6 patients left ventricle diastolicdysfunction was recognized. Valvular lesions were observed in 8 patients, but only in 2 patients werethey hemodynamically important. CONCLUSIONS: 24-hour Holter monitoring and echocardiography enable theearly detection of cardiovascular dysfunction in patients with systemic sclerosis presenting withoutapparent cardiac impairment symptoms.
Keywords: Adolescent, Cardiovascular System, Echocardiography, Electrocardiography, Scleroderma, Systemic
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952