11 March 2002
Effect of oral supplementation of free amino acids in type 2 diabetic patients: a pilot clinical trial.Sivaramakrishna Ramakrishnan, Tharigopala Arokiasamy, Baluswamy Sukumar, Soundarajan Lakshmi, Konerirajapuram Natarajan Sulochana, Ranganathan Punitham
Med Sci Monit 2002; 8(3): CR131-137 :: ID: 420914
BACKGROUND: Oral amino acid intake reduces plasma glucose in Streptozotocin-induceddiabetic rats. This study examined the effect of oral amino acid supplementation in patients with type2 diabetes mellitus (DM). MATERIAL/METHODS: A double blind pilot clinical trial was conducted for a periodof 2 months on 77 subjects with type 2 DM. Subjects of both sexes, ages 30-60, were included in the trial.All were receiving oral antidiabetic tablets. They were divided into groups on the basis of oral supplementation:(A) lysine, (B) essential amino acids, (C) amino acids and vitamins (fat and water-soluble), and (D)calcium phosphate (control). The subjects were periodically examined for fasting and post-prandial plasmaglucose, fasting and post-prandial immunoreactive insulin, plasma amino acids, glycosylated haemoglobin(HbA1c), proteins and albumin in serum, urea and creatinine in plasma and sugar, and proteins and ketonesin urine. RESULTS: The results revealed a significant decrease in PP plasma glucose (P<0.05) in group B when compared to groups C and D after 45 days. Plasma Arginine was increased in group C from 3.84 to 9.24 mg/dl. There were no statistically significant changes seen in other parameters between groups and visits.
Conclusions: Oral supplementation with amino acids for patients with type 2 DM appears to decrease PP plasma glucose without any change in plasma insulin levels, perhaps due to improved insulin sensitivity. However, the long term effects of amino acids need further study.
Keywords: Administration, Oral, Amino Acids, Antioxidants, Blood Glucose, Body Mass Index, Diabetes Mellitus, Type 2, Double-Blind Method, Insulin, Lysine, Pilot Projects
01 December 2021 : EditorialEditorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19
Med Sci Monit 2021; 27:e935624
03 December 2021 : Laboratory ResearchInfluenza and Influenza-Like Respiratory Virus Infections in Children During the 2019/20 Influenza Season a...
Med Sci Monit In Press; DOI: 10.12659/MSM.934862
08 November 2021 : Database AnalysisVirtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Cor...
Med Sci Monit In Press; DOI: 10.12659/MSM.934102
01 November 2021 : EditorialEditorial: What Can be Learned from National and International Vaccine Adverse Event Reporting Systems Duri...
Med Sci Monit 2022; 28:e935299
08 Dec 2021 : Review articleA Review of Emerging Biomarkers for Immune Checkpoint Inhibitors in Tumors of the Gastrointestinal Tract
Med Sci Monit In Press; DOI: 10.12659/MSM.935348
07 Dec 2021 : Review articleA Review of the Impact of Neutrophils and Neutrophil Extracellular Traps (NETs) on the Development of Aorti...
Med Sci Monit In Press; DOI: 10.12659/MSM.935134
07 Dec 2021 : Review articleAdie’s Pupil: A Diagnostic Challenge for the Physician
Med Sci Monit In Press; DOI: 10.12659/MSM.934657
Most Viewed Current Articles
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700