11 March 2002
Role of fasting serum C-peptide as a predictor of cardiovascular risk associated with the metabolic X-syndrome.
Peter Haban, Robert Simoncic, Eva Zidekova, Lubomir OzdinMed Sci Monit 2002; 8(3): CR175-179 :: ID: 420907
Abstract
BACKGROUND: Insulin resistance with increased insulin and C-peptide levelsis the basis of the metabolic X-syndrome, so it is reasonable to expect them to be a good predictor ofassociated cardiovascular risk factors. MATERIAL/METHODS: A total of 29 patients (21 postmenopausal womenand 8 men) with type 2 diabetes mellitus (mean duration 14.6 years, 95% CI 11.9 to 17.3 years), all olderthan 50, were studied for possible links between fasting serum C-peptide levels and other vascular riskfactors. The mean value of the C-peptide in the group was 0.627 nmol/l (95% CI: 0.464 to 0.789 nmol/l).RESULTS: We found statistically significant correlations between C-peptide and triacylglycerols (TG;r=0.474; p=0.009), HDL-cholesterol (inverse; r = -0.567; p = 0.001) and various lipoprotein ratios: atherogenicindex (= total/HDL cholesterol: r = 0.599; p = 0.0006) or TG/HDL (r = 0.587; p = 0.0008). C-peptide alsocorrelated with the body mass index (BMI: r = 0.519; p= 0.004) and leptin (r = 0.492; p = 0.007). Afterthe coefficient CpG (C-peptide x fasting glycemia) was introduced, the correlations with lipoproteinsbecame even stronger. CONCLUSIONS: We suggest that elevated (fasting) serum C-peptide levels constitutea clinically important marker of the cardiovascular risks associated with the metabolic X-syndrome. Itcan be used as an effective tool for the early detection of diabetic patients at particular risk foratherosclerotic cardiovascular diseases and needing early preventive measures or aggressive treatment.
Keywords: C-peptide, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Hyperlipoproteinemia, Insulin, Insulin Resistance, Lipoproteins, Metabolic Syndrome X, Peptides, Postmenopause, Risk Factors
Editorial
01 May 2022 : Editorial
Editorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19DOI: 10.12659/MSM.937048
Med Sci Monit 2022; 28:e937048
SARS-CoV-2/COVID-19
24 May 2022 : Clinical Research
Screening for SARS-CoV-2 Infection in Students at the Medical University of Warsaw, Poland Between November...Med Sci Monit In Press; DOI: 10.12659/MSM.936962
04 May 2022 : Clinical Research
Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...Med Sci Monit In Press; DOI: 10.12659/MSM.936069
22 April 2022 : Clinical Research
Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)Med Sci Monit In Press; DOI: 10.12659/MSM.936547
25 May 2022 : Meta-Analysis
Effect of the COVID-19 Pandemic on Serum Vitamin D Levels in People Under Age 18 Years: A Systematic Review...Med Sci Monit 2022; 28:e935823
In Press
25 May 2022 : Review article
Narrative Review of the Mechanism of Hip Prosthesis Dislocation and Methods to Reduce the Risk of DislocationMed Sci Monit In Press; DOI: 10.12659/MSM.935665
24 May 2022 : Clinical Research
Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing ...Med Sci Monit In Press; DOI: 10.12659/MSM.936580
24 May 2022 : Clinical Research
Screening for SARS-CoV-2 Infection in Students at the Medical University of Warsaw, Poland Between November...Med Sci Monit In Press; DOI: 10.12659/MSM.936962
23 May 2022 : Clinical Research
Fully Automatic Knee Joint Segmentation and Quantitative Analysis for Osteoarthritis from Magnetic Resonanc...Med Sci Monit In Press; DOI: 10.12659/MSM.936733
Most Viewed Current Articles
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review article
Long-Term Respiratory and Neurological Sequelae of COVID-19DOI :10.12659/MSM.928996
Med Sci Monit 2020; 26:e928996
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952