11 March 2002
Med Sci Monit 2002; 8(3): MT41-45 :: ID: 420898
BACKGROUND: The Total Cavopulmonary Connection (TCPC), used for repairof patients with single ventricle physiology, creates a passive system of blood flow into the pulmonarycirculation where enhanced energy efficiency may lead to improved long term patient outcomes. Previousnumerical and in vitro studies using steady flow have shown that incorporation of SVC (superior venacava) and IVC (inferior vena cava) offsets lead to decreased energy losses. We hypothesize that the optimalTCPC offset design found in these previous steady flow experiments may not be the optimal design in pulsatileflow situations. MATERIAL/METHODS: 3-D finite volume numerical models were used to simulate flow throughthe total cavopulmonary connection. We ran steady and pulsatile flow experiments through 4 TCPC designseach with different SVC to IVC offsets (0.1/4, 1/2, 1 diameter offsets). The total energy (power) lossfor each TCPC model was calculated. RESULTS: In steady flow experiments, % difference in energy lossbetween the most optimal and least optimal design was 26%. In contrast, in pulsatile flow experimentsthe % difference was only 8%. CONCLUSIONS: Our results demonstrate the improvements in energy loss seenusing SVC-IVC offsets in steady flow experiments do not necessarily translate to pulsatile flow situations.Overall there was lower differences in efficiency between all TCPC designs in the pulsatile flow experiments.These results emphasize the need for further studies to fully define the relationship between energylosses and TCPC vessel architecture in non-steady flow physiologic situations.
Keywords: Blood Flow Velocity, Cardiovascular System, Fontan Procedure, Hemodynamic Processes, Models, Theoretical, Regional Blood Flow, Research Support, Non-U.S. Gov, Time Factors
01 December 2021 : EditorialEditorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19
Med Sci Monit 2021; 27:e935624
03 December 2021 : Laboratory ResearchInfluenza and Influenza-Like Respiratory Virus Infections in Children During the 2019/20 Influenza Season a...
Med Sci Monit In Press; DOI: 10.12659/MSM.934862
08 November 2021 : Database AnalysisVirtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Cor...
Med Sci Monit In Press; DOI: 10.12659/MSM.934102
01 November 2021 : EditorialEditorial: What Can be Learned from National and International Vaccine Adverse Event Reporting Systems Duri...
Med Sci Monit 2022; 28:e935299
08 Dec 2021 : Review articleA Review of Emerging Biomarkers for Immune Checkpoint Inhibitors in Tumors of the Gastrointestinal Tract
Med Sci Monit In Press; DOI: 10.12659/MSM.935348
07 Dec 2021 : Review articleA Review of the Impact of Neutrophils and Neutrophil Extracellular Traps (NETs) on the Development of Aorti...
Med Sci Monit In Press; DOI: 10.12659/MSM.935134
07 Dec 2021 : Review articleAdie’s Pupil: A Diagnostic Challenge for the Physician
Med Sci Monit In Press; DOI: 10.12659/MSM.934657
Most Viewed Current Articles
20 Mar 2020 : Clinical ResearchSocial Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical ResearchPsychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review articleAn Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Med Sci Monit 2020; 26:e924700