Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

01 August 2005

Possible use of adaptation to hypoxia in Alzheimer's disease: a hypothesis.

Igor Malyshev, Frederik Wiegant, Svetlana Mashina, Vladimir Torshin, Anna Goryacheva, Inna Khomenko, Sergey Kruglov, Dmitry Pokidyshev, Elena Popkova, Maya Pshennikova, Mariya Vlasova, Olga Zelenina, Eugenia Manukhina

Med Sci Monit 2005; 11(8): HY36-38 :: ID: 199662

Abstract

Disorders in memory and other cognitive functions in Alzheimer's disease(AD) may result from an exhaustion of adaptive reserves in the brain. Therefore it is a challenge tofind methods to increase the adaptive reserve of the organism to combat AD. Excitotoxicity, Ca2(+) homeostasisdisruptions, oxidative stress, disturbed synthesis of NO, and impaired cerebral circulation are suggestedas key pathogenic factors of AD. At present it appears that stimulation of the self-defense systems inneural cells is a promising strategy in restricting the progression of AD. These systems include thoseof antioxidants, heat shock proteins (HSPs), NO, and other so-called stress-limiting systems. Non-drugactivation of these systems can be achieved most efficiently by adaptation of the organism to environmentalchallenges, such as hypoxia. In this paper the potential of methods used in adaptive medicine is explored.The protective mechanisms of adaptation to hypoxia may be related to restriction of oxidative stressin the hippocampus, the limitation of a decrease in NO production induced by b-amyloid, and increaseddensity of the vascular network in the brain. In this review we selectively present data that supportthe idea that adaptation to hypoxia is a possible non-drug means in the prevention of AD. In our opinionthis strategy may provide a break-through in the clinical approach of this disease.

Keywords: Alzheimer Disease - metabolism, Anoxia - metabolism, Adaptation, Physiological, Alzheimer Disease - therapy, Animals, Anoxia - metabolism, Cerebrovascular Circulation, Environment, Free Radicals - metabolism, HSP70 Heat-Shock Proteins - metabolism, Models, Biological, Nitric Oxide - metabolism, Oxidation-Reduction

0 Comments

This Week Editorial

20 September 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934766

Med Sci Monit 2021; 27:e934766

Coronavirus/Covid 19

22 September 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

23 Sep 2021 : Animal Research

Forkhead Box Protein M1 Promotes Nasopharyngeal Carcinoma Cell Tumorigenesis Possibly via the Wnt/β-Catenin...

Med Sci Monit In Press; DOI: 10.12659/MSM.931970  

22 Sep 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

22 Sep 2021 : Clinical Research

A Comparative Study of the Clinical Efficacy and Safety of Pneumatic Trabeculoplasty and Selective Laser Tr...

Med Sci Monit In Press; DOI: 10.12659/MSM.933454  

20 Sep 2021 : Clinical Research

Comparison of the Use of Magnetic Resonance Imaging of Partial Anterior Cruciate Ligament Tears Using Maxim...

Med Sci Monit In Press; DOI: 10.12659/MSM.932228  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750