Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 2005 : Original article  

Placental Leucine Aminopeptidase Might Regulate the Effects of Oxytocin with Resolution in Endothelial Cells.

Michiyo Sano, Atsuo Itakura, Mitsuaki Ito, Mikihito Takeuchi, Mayumi Okada, Tomomi Kotani, Shigehiko Mizutani, Fumitaka Kikkawa

Med Sci Monit 2005; 11(7): BR195-199 :: ID: 16970

Abstract

Background: Oxytocin (OT) is known to cause vascular relaxation via nitricoxide (NO) production and proliferation of endothelial cells. Previously we revealed that human umbilicalvascular endothelial cells (HUVECs) expresses placental leucine aminopeptidase (P-LAP)/insulin regulatedaminopeptidase (IRAP), which becomes translocation to the cell surface on activation of oxytocin receptor(OTR). However, the physiological roles of P-LAP in HUVECs have not been elucidated. Material/Methods:Actions of OT on HUVECs transfected with a copy of the human P-LAP gene were therefore examined witha focus on changes in parameters linked to OTR such as calcium mobilization, NO production and cell proliferation.Results: Cell surface P-LAP activity was significantly elevated (~3 fold) in P-LAP overexpressing-HUVECsand overexpression of P-LAP resulted in remarkable inhibition of OT effects on HUVECs such as cell proliferation,[Ca(2+)]i, and NO production. Conclusions: These findings suggested that P-LAP on the plasma membranein HUVECs regulates the effects of OT with resolution around OTR.

Keywords: Cystinyl Aminopeptidase - biosynthesis, Cystinyl Aminopeptidase - genetics, Calcium - metabolism, Cell Proliferation - drug effects, Cells, Cultured, Cystinyl Aminopeptidase - genetics, Endothelial Cells - metabolism, Endothelium, Vascular - metabolism, Nitric Oxide - biosynthesis, Oxytocin - pharmacology, Umbilical Veins - cytology, Vasodilator Agents - pharmacology

0 Comments

Editorial

01 May 2022 : Editorial  

Editorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937048

Med Sci Monit 2022; 28:e937048

SARS-CoV-2/COVID-19

16 May 2022 : Clinical Research  

Importance of Influenza Anti-Hemagglutinin Antibodies During the SARS-CoV-2 Pandemic in the 2019/2020 Epide...

Med Sci Monit In Press; DOI: 10.12659/MSM.936495  

04 May 2022 : Clinical Research  

Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...

Med Sci Monit In Press; DOI: 10.12659/MSM.936069  

22 April 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit In Press; DOI: 10.12659/MSM.936547  

27 April 2022 : Meta-Analysis  

Effect of the COVID-19 Pandemic on Serum Vitamin D Levels in People Under Age 18 Years: A Systematic Review...

Med Sci Monit In Press; DOI: 10.12659/MSM.935823  

In Press

17 May 2022 : Clinical Research  

Clinical Application of C-TIRADS Category and Contrast-Enhanced Ultrasound in Differential Diagnosis of Sol...

Med Sci Monit In Press; DOI: 10.12659/MSM.936368  

17 May 2022 : Laboratory Research  

Artificial Dermal Scaffold Loaded with Platelet-Rich Plasma Promotes Wound Healing in Pigs by Favoring Angi...

Med Sci Monit In Press; DOI: 10.12659/MSM.936186  

16 May 2022 : Clinical Research  

Early Enteral Nutrition Can Reduce Incidence of Postoperative Hydrocephalus in Patients with Severe Hyperte...

Med Sci Monit In Press; DOI: 10.12659/MSM.935850  

16 May 2022 : Clinical Research  

Importance of Influenza Anti-Hemagglutinin Antibodies During the SARS-CoV-2 Pandemic in the 2019/2020 Epide...

Med Sci Monit In Press; DOI: 10.12659/MSM.936495  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750