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A comparative study of the role of erythropoietin in the pathogenesis of deficient erythropoiesis in idiopathic pulmonary fibrosis as opposed to chronic obstructive pulmonary disease

Argirios Tsantes, Stefanos Bonovas, Stergios Tassiopoulos, Kalitsa Filioussi, Athina Vlachou, John Meletis, Stefanos Papadhimitriou, George Vaiopoulos

Med Sci Monit 2005; 11(4): CR177-181

ID: 15880

Available online: 2005-04-01

Published: 2005-04-01

Background:Despite the severe derangement of gas exchange in the advanced stages of idiopathic pulmonary fibrosis (IPF), secondary erythrocytosis is either absent or much lower than is seen in chronic obstructive pulmonary disease (COPD) with comparable hypoxemia. This study investigates the differences in erythropoiesis between IPF and COPD, searching for the possible underlying mechanisms. Material/Methods:The study included 32 patients with COPD, 18 patients with IPF, all with overt hypoxemia (PO[sub]2[/sub]

Keywords: Anoxemia - blood, Anoxemia - physiopathology, Erythroid Progenitor Cells - cytology, Erythroid Progenitor Cells - pathology, Erythroid Progenitor Cells - physiology, Erythropoiesis - physiology, Erythropoietin - blood, Pulmonary Fibrosis - blood, Pulmonary Fibrosis - physiopathology, Aged, Anoxia - physiopathology, Blood Gas Analysis, Erythrocyte Count, Erythroid Precursor Cells - physiology, Erythropoiesis - physiology, Erythropoietin - blood, Female, Hemoglobins - metabolism, Humans, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive - physiopathology, Pulmonary Fibrosis - physiopathology