01 March 2005 : Original article
Autologous gamete cryopreservation before hemopoietic stem cell transplantation
Takahiro Nagashima, Kazuo Muroi, Chizuru Kawano-Yamamoto, Takuji Miyoshi, Ken Ohmine, Masaki Toshima, Akira Miyazato, Masaaki Takatoku, Tadashi Nagai, Masaki Mori, Norio Komatsu, Keiya OzawaMed Sci Monit 2005; 11(3): CR91-94 :: ID: 15383
Abstract
Background: Infertility after hemopoietic stem cell transplantation (HST) is a serious problem for young patients. Autologous gamete collection before HST may be a promising strategy to overcome infertility.
Material/Methods: From October 1988 to December 2003, six male and nine female patients with hematological malignancies had autologous gametes collected before HST. The data on autologous gamete collection were analyzed.
Results: Sperm could be collected from three patients. However, in two of the three, the numbers and motility of the sperm were severely depleted because they received chemotherapy for one and 11 cycles,
respectively. Normal sperm was only collected from one patient with myelodysplastic syndrome who had no history of receiving chemotherapy. One or more oocytes could be collected in fi ve of
nine female patients, although the fi ve received multiple cycles of chemotherapy. The successful oocyte collection was associated with an ovulation stimulant.
Conclusions: Autologous oocye collection before HST may be possible, even if patients receive multiple cycles of chemotherapy. In contrast, autologous sperm collection before HST may be diffi cult after patients
receive chemotherapy. Successful pregnancy using autologous gametes after HST remains extremely diffi cult, especially in female patients; however, it is important to give information on infertility and autologous gamete collection to patients scheduled for HST.
Keywords: Germ Cells - physiology, Hematologic Neoplasms - drug therapy, Infertility, Female - etiology, Adolescent, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Cryopreservation, Germ Cells - physiology, Hematologic Neoplasms - drug therapy, Infertility, Female - etiology, Infertility, Male - etiology, Japan, Oocytes - physiology, Pregnancy, Specimen Handling - methods, Spermatozoa - physiology, Transplantation, Autologous
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Comparing Neuromuscular Blockade Measurement Between Upper Arm (TOF Cuff®) and Eyelid (TOF Scan®) Using Miv...Med Sci Monit In Press; DOI: 10.12659/MSM.943630
11 Mar 2024 : Clinical Research
Enhancement of Frozen-Thawed Human Sperm Quality with Zinc as a Cryoprotective AdditiveMed Sci Monit In Press; DOI: 10.12659/MSM.942946
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952