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Medical Science Monitor Basic Research


eISSN: 1643-3750

Autologous gamete cryopreservation before hemopoietic stem cell transplantation

Takahiro Nagashima, Kazuo Muroi, Chizuru Kawano-Yamamoto, Takuji Miyoshi, Ken Ohmine, Masaki Toshima, Akira Miyazato, Masaaki Takatoku, Tadashi Nagai, Masaki Mori, Norio Komatsu, Keiya Ozawa

Med Sci Monit 2005; 11(3): CR91-94

ID: 15383

Available online: 2005-03-01

Published: 2005-03-01

Background: Infertility after hemopoietic stem cell transplantation (HST) is a serious problem for young patients. Autologous gamete collection before HST may be a promising strategy to overcome infertility.
Material/Methods: From October 1988 to December 2003, six male and nine female patients with hematological malignancies had autologous gametes collected before HST. The data on autologous gamete collection were analyzed.
Results: Sperm could be collected from three patients. However, in two of the three, the numbers and motility of the sperm were severely depleted because they received chemotherapy for one and 11 cycles,
respectively. Normal sperm was only collected from one patient with myelodysplastic syndrome who had no history of receiving chemotherapy. One or more oocytes could be collected in fi ve of
nine female patients, although the fi ve received multiple cycles of chemotherapy. The successful oocyte collection was associated with an ovulation stimulant.
Conclusions: Autologous oocye collection before HST may be possible, even if patients receive multiple cycles of chemotherapy. In contrast, autologous sperm collection before HST may be diffi cult after patients
receive chemotherapy. Successful pregnancy using autologous gametes after HST remains extremely diffi cult, especially in female patients; however, it is important to give information on infertility and autologous gamete collection to patients scheduled for HST.

Keywords: Germ Cells - physiology, Hematologic Neoplasms - drug therapy, Infertility, Female - etiology, Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Cryopreservation, Germ Cells - physiology, Hematologic Neoplasms - drug therapy, Hematopoietic Stem Cell Transplantation, Infertility, Female - etiology, Infertility, Male - etiology, Japan, Oocytes - physiology, Pregnancy, Specimen Handling - methods, Spermatozoa - physiology, Transplantation, Autologous